Results 61 to 70 of about 9,596 (243)

Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress [PDF]

, 2020
BACKGROUND: Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment.
Abdelhamid, Mahmoud A S, Amparo, Camille, Bedell, Victoria, Clark, Jarrod, Martella, Marianna, Murata-Collins, Joyce L, Pichiorri, Flavia, Smith, Steven S, Waller, Zoë A E, Warner, Emily F   +9 more
core   +2 more sources

Cpg-ODN, a TLR9 Agonist, Aggravates Myocardial Ischemia/Reperfusion Injury by Activation of TLR9-P38 MAPK Signaling

Cellular Physiology and Biochemistry, 2018
Background/Aims: Toll-like receptors (TLRs) have been implicated in myocardial ischemia/ reperfusion (I/R) injury. We examined the effect of CpG-oligodeoxynucleotide (ODN) on myocardial I/R injury.
Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu, Jianbin Gong   +8 more
doaj   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells [PDF]

, 2013
Background The potential use of nucleic acids as therapeutic drugs has triggered the quest for oligonucleotide conjugates with enhanced cellular permeability.
Alkorta, Itziar, Busto, Jon V., Eritja Casadellà, Ramón, Goñi, Félix Lix M, Grijalvo, Santiago, Martín, César, Ugarte-Uribe, Begoña   +6 more
core   +1 more source

The Effect of TLR9 Agonist CpG Oligodeoxynucleotides on the Intestinal Immune Response of Cobia (Rachycentron canadum)

Journal of Immunology Research, 2014
Cytosine-guanine oligodeoxynucleotide (CpG ODN) motifs of bacterial DNA are recognized through toll-like receptor 9 (TLR9) and are potent activators of innate immunity.
Omkar Byadgi, Dinda Puteri, Jai-Wei Lee, Tsung-Chou Chang, Yan-Horn Lee, Chun-Yen Chu, Ta-Chih Cheng   +6 more
doaj   +1 more source

Reduction of CpG‐induced arthritis by suppressive oligodeoxynucleotides [PDF]

Arthritis & Rheumatism, 2002
AbstractObjectiveBacterial DNA contains immunostimulatory CpG motifs that cause inflammation when injected into the knee joints of normal mice. We examined whether synthetic oligodeoxynucleotides (ODN) that suppress CpG‐induced immune responses prevent CpG‐induced arthritis.MethodsCpG, suppressive, and/or control ODN were injected into the knees of ...
Rainald A, Zeuner, Ken J, Ishii, Martin J, Lizak, Ihsan, Gursel, Hiroshi, Yamada, Dennis M, Klinman, Daniela, Verthelyi   +6 more
openaire   +2 more sources

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology. [PDF]

, 2008
It seems well established that CpG oligonucleotides Th1 biased adjuvant activity can be improved when closely associated with a variety of antigens in, for example, microparticles.
Espuelas, S. (Socorro), Gamazo, C. (Carlos), Gomez, S. (Sara), Irache, J.M. (Juan Manuel), San-Roman, B. (Beatriz), Tsapis, N. (Nicolás)   +5 more
core  

Non-CpG Oligonucleotides Exert Adjuvant Effects by Enhancing Cognate B Cell-T Cell Interactions, Leading to B Cell Activation, Differentiation, and Isotype Switching

Journal of Immunology Research, 2015
Natural and synthetic nucleic acids are known to exert immunomodulatory properties. Notably, nucleic acids are known to modulate immune function via several different pathways and various cell types, necessitating a complex interpretation of their ...
Melinda Herbáth, Krisztián Papp, Anna Erdei, József Prechl   +3 more
doaj   +1 more source

Improved Messenger RNA Stability and Biocompatibility Through Self‐Gelatinizable Nucleic Acids

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA‐based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems.
Takumi Tanifuji, Kosuke Kusamori, Chihiro Tanaka, Hideki Sakai, Shoko Itakura, Makiya Nishikawa   +5 more
wiley   +1 more source