Results 61 to 70 of about 5,254 (231)

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.
Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira, Noah D. Cohen, Sara D. Lawhon, Robert O. Watson, Angela I. Bordin   +4 more
wiley   +1 more source

Cytidine-phosphate-guanosine oligodeoxynucleotides in combination with CD40 ligand decrease periodontal inflammation and alveolar bone loss in a TLR9-independent manner

Journal of Applied Oral Science, 2018
Local administration of toll-like receptor 9 (TLR9), agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG ODNs), and CD40 ligand (CD40L) can decrease ligature-induced periodontal inflammation and bone loss in wild type (WT) mouse.
Qian Zhao, Yang Hu, Shu Deng, Pei Yu, Bowen Chen, Zuomin Wang, Xiaozhe Han   +6 more
doaj   +1 more source

CpG Oligodeoxynucleotides as a Future Vaccine for Allergic Diseases

Allergology International, 2005
ABSTRACTAn astounding feature of the DNA sequences termed CpG motifs is the induction of immune and inflammatory responses in a senseless manner. CpG motifs exist abundantly in microbes and evoke innate immunity that constitutes the first line of defense against microbial infections in vertebrates.
Kunio Sano, Hidekazu Shirota
openaire   +3 more sources

Universal Prophylactic Antitumor Vaccination Using Stem Cell Membrane‐Coated Nanoparticles

Advanced Materials, Volume 37, Issue 14, April 9, 2025.
Induced pluripotent stem cell membrane is coated onto adjuvant‐loaded nanoparticle cores to create a universal cancer vaccine. The formulation utilizes oncofetal antigens present on the cell membrane to elicit broadly protective immune responses in vivo.
Nishta Krishnan, Jiarong Zhou, Animesh Mohapatra, Christian John Ventura, Yaou Duan, Junyong Lee, Jacob J. Hoenig, Oliver Nizet, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang   +10 more
wiley   +1 more source

Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen

Frontiers in Immunology, 2018
There is a need for new vaccine adjuvant strategies that offer both vigorous antibody and T-cell mediated protection to combat difficult intracellular pathogens and cancer.
Ana L. Chiodetti, Ana L. Chiodetti, María F. Sánchez Vallecillo, María F. Sánchez Vallecillo, Joseph S. Dolina, María I. Crespo, María I. Crespo, Constanza Marin, Constanza Marin, Stephen P. Schoenberger, Daniel A. Allemandi, Daniel A. Allemandi, Santiago D. Palma, Santiago D. Palma, María C. Pistoresi-Palencia, María C. Pistoresi-Palencia, Gabriel Morón, Gabriel Morón, Belkys A. Maletto, Belkys A. Maletto   +19 more
doaj   +1 more source

Programming Injectable DNA Hydrogels Yields Tumor Microenvironment‐Activatable and Immune‐Instructive Depots for Augmented Chemo‐Immunotherapy

Advanced Science, 2023
Injectable hydrogels have attracted increasing attention for promoting systemic antitumor immune response through the co‐delivery of chemotherapeutics and immunomodulators.
Yu Fan, Mengsi Zhan, Junhao Liang, Xingsen Yang, Beibei Zhang, Xiangyang Shi, Yong Hu   +6 more
doaj   +1 more source

CpG‐Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2‐Mediated Remodeling of Tumor‐Associated Macrophages

Advanced Science, Volume 12, Issue 15, April 17, 2025.
CpG‐based nanovaccines bolster ovarian cancer immunotherapy via the Gbp2‐Pin1‐NFkB pathway‐mediated reprogramming of tumor‐associated macrophages (TAMs.) Moreover, this nanovaccine can alleviate chemotherapy‐induced immunosuppression by augmenting the proportion of M1‐like TAMs, enhancing the infiltration of CD8+ T cells, and downregulating the ...
Jiaqiang Xiong, Juyuan Huang, Hanxiao Xu, Qiuji Wu, Jiahui Zhao, Yurou Chen, Guanlan Fan, Haotong Guan, Rourou Xiao, Zhaojin He, Siqi Wu, Wenliang Ouyang, Shixuan Wang, Lu Zhang, Peng Xia, Wei Zhang, Meng Wu   +16 more
wiley   +1 more source

Data on the uptake of reducible antigen-adjuvant conjugates by dendritic cells

Data in Brief, 2019
This article contains the uptake data of two reducible antigen-adjuvant conjugates with different sensitivities to the extracellular and intracellular reductive environment.
Katrin Kramer, Sarah L. Young, Greg F. Walker   +2 more
doaj  

Time-Resolved Emission Study of a Thiophene-Modified Fluorescent Nucleoside in Solution and within Multiply-Modified Oligodeoxynucleotides [PDF]

arXiv, 2014
Steady-state and time-resolved emission techniques were employed to study the photophysical properties of 5-(thien-2-yl)-2'-deoxyuridine (dUTh), an isomorphic fluorescent nucleoside analog. We found that the emission lifetime of dUTh is dependent upon the solvent viscosity and obeys the F\"orster-Hoffman relation over a wide range of temperatures in 1 ...
arxiv  

STAT3 Signaling Pathway in Health and Disease

MedComm, Volume 6, Issue 4, April 2025.
An image depicting the role of STAT3 in various human diseases ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor involved in multiple physiological and pathological processes. While STAT3 plays an essential role in homeostasis, its persistent activation has been implicated in the pathogenesis of ...
Md Abdus Samad, Iftikhar Ahmad, Aakifah Hasan, Mohammad Hassan Alhashmi, Arusha Ayub, Fahad A. Al‐Abbasi, Ajoy Kumer, Shams Tabrez   +7 more
wiley   +1 more source