Results 71 to 80 of about 5,254 (231)

Identifying Epigenetic Signature of Breast Cancer with Machine Learning [PDF]

arXiv, 2019
The research reported in this paper identifies the epigenetic biomarker (methylation beta pattern) of breast cancer. Many cancers are triggered by abnormal gene expression levels caused by aberrant methylation of CpG sites in the DNA. In order to develop early diagnostics of cancer-causing methylations and to develop a treatment, it is necessary to ...
arxiv  

Implantable Biomaterials for Cancer Immunotherapies

Advanced Functional Materials, Volume 35, Issue 10, March 4, 2025.
This review discusses the current developments in the use of IBs for cancer immunotherapy. The focus is on their potential to enhance immune responses, modulate the tumor microenvironment, and deliver therapeutic agents. Key challenges such as biocompatibility, surgical requirements, and patient response variability are also addressed, alongside future
Nadezhda A. Pechnikova, Amalia Aggeli, Anastasiia A. Latypova, Aleksandra V. Iaremenko, Kalliopi Domvri, Ilya V. Zubarev, Chuang Liu, Alexey V. Yaremenko   +7 more
wiley   +1 more source

CpG-oligodeoxynucleotide-resistant variant of WEHI 231 cells [PDF]

Journal of Leukocyte Biology, 1999
Abstract Bacterial DNA and synthetic single-stranded oligonucleotides having unmethylated CpG motifs (CpG-ODN) powerfully stimulate cellular immune responses by an unknown mechanism. There is evidence that internalization of the nucleotide is required for activity.
Donald E. Macfarlane, Lori Manzel
openaire   +3 more sources

Effects of KLK Peptide on Adjuvanticity of Different ODN Sequences

Vaccines, 2016
Endosomal Toll-like receptors (TLR) such as TLR3, 7, 8 and 9 recognize pathogen associated nucleic acids. While DNA sequence does influence degree of binding to and activation of TLR9, it also appears to influence the ability of the ligand to reach the ...
Ghania Chikh, Rachel Luu, Shobhna Patel, Heather L. Davis, Risini D. Weeratna   +4 more
doaj   +1 more source

Protein‐DNA Competition at the Bio‐Nano Interface: Structural and Biological Insights From Graphene Oxide Coronas

Advanced Materials Interfaces, Volume 12, Issue 6, March 16, 2025.
This study explores how DNA affects protein corona formation on Graphene Oxide nanosheets in DNA‐supplemented human plasma. DNA introduction shifts the corona from protein‐dominated to a 2‐component biomolecular corona composed of proteins and DNA. Higher DNA concentration in the corona correlates with increased Toll‐like receptor 9 (TLR9) activation ...
Erica Quagliarini, Francesca Giulimondi, Serena Renzi, Andrea Pirrottina, Alessandra Zingoni, Nicholas Carboni, Daniela Pozzi, Giulio Caracciolo   +7 more
wiley   +1 more source

Ferumoxytol and CpG oligodeoxynucleotide 2395 synergistically enhance antitumor activity of macrophages against NSCLC with EGFRL858R/T790M mutation

International Journal of Nanomedicine, 2019
Guoqun Wang,1 Jiaojiao Zhao,2 Meiling Zhang,1 Qian Wang,1 Bo Chen,3 Yayi Hou,2,4 Kaihua Lu11Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; 2The State Key Laboratory ...
Wang G, Zhao J, Zhang M, Wang Q, Chen B, Hou Y, Lu K   +6 more
doaj  

TLR9 ligand induces the generation of CD20+ plasmablasts and plasma cells from CD27+ memory B-cells

Frontiers in Immunology, 2011
Plasma cells have a heterogeneous phenotype in humans. While bone marrow plasma cells are CD20-CD138+, tonsil plasma cells are CD20+CD138+/- and peripheral plasmablasts are CD20-CD138-.
Alexandrine eGeffroy-Luseau, Alexandrine eGeffroy-Luseau, David eChiron, David eChiron, Géraldine eDescamps, Géraldine eDescamps, Gaëtan eJégo, Gaëtan eJégo, Martine eAmiot, Martine eAmiot, Catherine ePellat-Deceunynck, Catherine ePellat-Deceunynck   +11 more
doaj   +1 more source

Photothermal Therapy: From Encouraging Lab Results to Lackluster Clinical Translation

Advanced Therapeutics, Volume 8, Issue 3, March 2025.
Photothermal therapy (PTT) holds promise for non‐invasive cancer treatment by inducing localized tumor cell death. However, despite extensive laboratory progress and the selective potential of agents like gold nanoshells, clinical translation lags.
Jonathan Buiel, Jordan Robert, Dikran Mekhjian, Deepak S. Chauhan, Xavier Banquy   +4 more
wiley   +1 more source

Synthesis of Oligodeoxynucleotide Containing Pseudo‐Deoxycytidine and Its Triphosphate Derivative

Current Protocols, Volume 5, Issue 3, March 2025.
Abstract This article describes a detailed synthetic protocol for the preparation of oligodeoxynucleotide (ODN) containing pseudo‐deoxycytidine (ψdC) and its triphosphate derivative (ψdCTP). These molecules were synthesized as novel compounds that recognize iso‐2'‐deoxyguanosine (iso‐dG) in DNA.
Ryo Miyahara, Yosuke Taniguchi
wiley   +1 more source

Topology of Central Pattern Generators: Selection by Chaotic Neurons [PDF]

arXiv, 1999
Central Pattern Generators (CPGs) in invertebrates are comprised of networks of neurons in which every neuron has reciprocal connections to other members of the CPG. This is a ``closed'' network topology. An ``open'' topology, where one or more neurons receives input but does not send output to other member neurons, is not found in these CPGs.
arxiv