Results 91 to 99 of about 146 (99)

HIV-1-induced translocation of CPSF6 to biomolecular condensates

Trends in Microbiology
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6, also known as CFIm68) is a 68 kDa component of the mammalian cleavage factor I (CFIm) complex that modulates mRNA alternative polyadenylation (APA) and determines 3' untranslated region (UTR) length, an important gene expression control mechanism.
Katarzyna Bialas, Felipe Diaz-Griffero
openaire   +2 more sources

Expression of zebrafish cpsf6 in embryogenesis and role of protein domains on subcellular localization

Gene Expression Patterns, 2020
CPSF6 is a component of the CFIm complex, involved in mRNA 3'end processing. Despite increasing interest on this protein as a consequence of proposed roles in cancer and HIV infection, several aspects of CPSF6 biological function are poorly understood.
Borini Etichetti, Carla Maria, Tenaglia, Albano Heraldo, Arroyo, María Nicol, Girardini Brovelli, Javier Enrique   +3 more
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Detection of CPSF6 in Biomolecular Condensates as a Reporter of HIV-1 Nuclear Import

The initial stages of HIV-1 infection involve the transport of the viral core into the nuclear compartment. The presence of the HIV-1 core in the nucleus triggers the translocation of CPSF6/CPSF5 from paraspeckles into nuclear speckles, forming puncta-like structures.
Charlotte, Luchsinger, Felipe, Diaz-Griffero   +1 more
openaire   +2 more sources

[The nuclear translocation of circRNA CPSF6 promotes apoptosis of trophoblast cells induced by homocysteine].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2022
Objective To investigate the role of circular RNA cleavage and polyadenylation specificity factor 6 (circRNA CPSF6) in the apoptosis of trophoblast cells induced by homocysteine (Hcy) and its mechanism. Methods HTR-8/SVneo human chorionic trophoblast cells were cultured in vitro and divided into control group (0 mmol/L Hcy treatment) and 1 mmol/L Hcy ...
Lina, Gao, Qirui, Wu, He, Yin, Linying, Liu, Yuzhu, Wu, Yuyue, Zhang, Yanhua, Wang, Kai, Wu, Huiping, Zhang   +8 more
openaire   +1 more source

m6A-mediated regulation of CPSF6 by METTL3 promotes oxaliplatin resistance in colorectal cancer through enhanced glycolysis

Cellular Signalling
Oxaliplatin resistance poses a significant challenge in colorectal cancer (CRC) treatment. Recent studies have implicated CPSF6 in cancer progression and drug resistance, although its role in chemotherapy resistance and regulatory mechanisms is unclear.
Chengxing, Wang, Weijun, Liang, Jietao, Zhong, Jiachen, Liu, Chaorong, Zhou, Changyi, Ma, Yuehua, Liao, Yuan, Gao, Jinglin, Zhao, Yaoming, He   +9 more
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The Oncogenic Role and Potential Treatment of a Novel CPSF6-Rarg Fusion in Myeloid Transformation

Blood, 2022
Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Suning Chen, Yang Xu, Depei Wu   +6 more
openaire   +1 more source

Identification of a novel CPSF6-RARG fusion transcript in acute myeloid leukemia resembling acute promyelocytic leukemia

Leukemia, 2018
Ya-Zhen Qin, Xiao-Jun Huang, Hong-Hu Zhu
openaire   +2 more sources

CPSF6 antibody | knockout validation | Abcam ab175237 | Bethyl Laboratories A301-358A

Materials and Methods, 2016
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CPSF6 loss mediates LDHA 3’UTR shortening to promote fibroblast glycolysis and pulmonary fibrosis

Cellular Signalling
Huanyu Yang, Mengjia Han, Li Zhang, Changhong Yao, Qi Xu   +4 more
openaire   +1 more source