Results 61 to 70 of about 68,665 (303)

Fatigue crack growth in notched specimens: a numerical analysis

open access: yesFracture and Structural Integrity, 2019
Fatigue crack growth (FCG) is linked to irreversible and non-linear processes happening at the crack tip, which explains different problems observed in the use of da/dN-?K curves. The replacement of ?K by non-linear crack tip parameters, namely the crack
F.V. Antunes   +3 more
doaj   +3 more sources

A finite element analysis of fatigue crack closure [PDF]

open access: yes
Experiments have shown that fatigue cracks close at positive loads during constant-amplitude load cycling. The crack-closure phenomenon is caused by residual plastic deformations remaining in the wake of an advancing crack tip.
Newman, J. C., Jr.
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Crack Closure Effects on Fatigue Crack Propagation Rates: Application of a Proposed Theoretical Model

open access: yesAdvances in Materials Science and Engineering, 2016
Structural design taking into account fatigue damage requires a thorough knowledge of the behaviour of materials. In addition to the monotonic behaviour of the materials, it is also important to assess their cyclic response and fatigue crack propagation ...
José A. F. O. Correia   +3 more
doaj   +1 more source

Investigation of plasticity-induced fatigue crack closure [PDF]

open access: yes, 2007
Plasticity induced crack closure and constraint effects due to finite plate thickness are both fundamental aspects in the mechanics of fatigue cracks. Moreover, plasticity induced crack closure provides an effective first-order correction to the crack ...
Codrington, John, Kotousov, Andrei
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Closure Effect of I + II Mixed-mode Crack for EA4T Axle Steel

open access: yesChinese Journal of Mechanical Engineering
The crack-closure effect is a crucial factor that affects the crack growth rate and should be considered in simulation analysis and testing. A mixed-mode I + II loading fatigue crack growth test was performed using EA4T axle steel specimens.
Shuancheng Wang   +4 more
doaj   +1 more source

Near-threshold fatigue propagation of physically through-thickness short and long cracks in a low alloy steel [PDF]

open access: yes, 2014
International audienceIn this paper, the near-threshold fatigue behavior of physically through-thickness short cracks and of long cracks in a low alloy steel is investigated by experiments in ambient air. Physically through-thickness short fatigue cracks
Chretien, Gaëlle   +5 more
core   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Through-the-thickness fatigue crack closure behavior in an aluminum alloy [PDF]

open access: yes
The variation in fatigue crack closure behavior across the thickness of aluminum alloy specimens was investigated. The specimen geometries examined were the middle crack tension M(T) and compact tension C(T).
Dawicke, D. S.   +2 more
core   +1 more source

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