Results 71 to 80 of about 68,841 (302)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Metals, 2019 This study deals with the influence of microstructure on the fatigue crack growth resistance of αβ titanium alloys: Ti-6Al-4V ELI (Extra Low Interstitial) that may compete with the conventional Ti-6Al-4V alloy in the manufacture of high ...
Vincent Renon +4 more
doaj +1 more source
Predicting fatigue crack growth rate in a welded butt joint: The role of effective R ratio in accounting for residual stress effect [PDF]
, 2009 A simple and efficient method is presented in this paper for predicting fatigue crack growth rate in welded butt joints. Three well-known empirical crack growth laws are employed using the material constants that were obtained from the base material ...
Servetti, Guido, Zhang, X.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Through-the-thickness fatigue crack closure behavior in an aluminum alloy [PDF]
The variation in fatigue crack closure behavior across the thickness of aluminum alloy specimens was investigated. The specimen geometries examined were the middle crack tension M(T) and compact tension C(T).
Dawicke, D. S. +2 more
core +1 more source
A numerical analysis of the plastic wake influence on plasticity induced crack closure [PDF]
, 2017 Fatigue crack closure has been studied by means of finite element method since long time ago. Most work has been performed considering bi-dimensional models. Lately, the use of threedimensional models has been extended.
Antunes, F.V. +3 more
core
Permanent indentation characterization for low-velocity impact modelling using three-point bending test [PDF]
, 2013 This paper deals with the origin of permanent indentation in composite laminates subjected to low-velocity impact. The three-point bending test is used to exhibit a non-closure of matrix crack which is assumed as a cause of permanent indentation ...
Bouvet, Christophe +3 more
core +3 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Controlling fatigue crack paths for crack surface marking and growth investigations
Fracture and Structural Integrity, 2015 While it is well known that fatigue crack growth in metals that display confined slip, such as high strength aluminium alloys, develop crack paths that are responsive to the loading direction and the local microstructural orientation, it is less well ...
S. Barter, P. White, M. Burchill
doaj +3 more sources
AerospaceVariable amplitude fatigue loading can result in both accelerated and decelerated fatigue damage due to load interaction effects. Short fatigue cracks in particular exhibit a wide range of crack growth behavior due to multiple damage mechanisms ...
Robert Fleishel +2 more
doaj +1 more source