Modeling of crack bridging in a unidirectional metal matrix composite [PDF]
The effective fatigue crack driving force and crack opening profiles were determined analytically for fatigue tested unidirectional composite specimens exhibiting fiber bridging. The crack closure pressure due to bridging was modeled using two approaches;
Ghosn, Louis J. +2 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
In situ measurement of fatigue crack opening stresses by nonlinear vibro-acoustic modulation testing
Advances in Mechanical Engineering, 2017 The difficulty of accurately measuring crack closure regions has hindered measurements of opening or closure stresses, and ultrasonic methods have shown great potentialities in evaluating closure area. Many recent researches have confirmed the advantages
Jun Jia +3 more
doaj +1 more source
Research on the Evolution Law Physical Short Fatigue Crack and Tip Deformation Fields during Crack Closure Process of the Q&P Steel. [PDF]
Materials (Basel), 2022 Shang H, Lin Z, Gao H, Shan X, Zhan J.
europepmc +1 more source
Variables controlling fatigue crack growth of short cracks [PDF]
A study was conducted to evaluate the roles of crack closure and microstructure in the fatigue growth of short cracks. Testing was performed at R ratios of 0.1, 0.5, and 0.7.
Fisher, D. M., Holka, D., Telesman, J.
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Effect of Underload Cycles on Oxide-Induced Crack Closure Development in Cr-Mo Low-Alloy Steel. [PDF]
Materials (Basel), 2021 Pokorný P +4 more
europepmc +1 more source
Fatigue crack closure and closure development in a high strength aluminium alloy [PDF]
, 2015 A dissertation submitted to the Faculty of Engineering, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Engineering.
Garz, Reiner Ernst
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Numerical Simulation of the Effect of Pre-Strain on Fatigue Crack Growth in AA2024-T351
MetalsThe objective here is to study the effect of pre-strain on fatigue crack growth (FCG) in 2024-T351 aluminum alloy. Three pre-strain conditions were considered: without pre-strain, compressive and tensile permanent pre-strains of 4%.
Diogo M. Neto +3 more
doaj +1 more source