Results 91 to 100 of about 58,593 (304)

Innovative reinforcement techniques for 3D-printed concrete: The impact of shape memory alloys on flexural strength and crack mitigation

Next Materials
The flexural performance (FP) of 3D Printed Concrete (3DPC) remains a challenge due to its limitations in tensile strength and resistance to cracking. To address these issues, innovative reinforcement materials, such as Shape Memory Alloys (SMAs), which ...
Ronak Motiani, Saha Keunang Sylvain, Sejal P. Dalal, Jay Vora, Rakesh Chaudhari   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Influence of roughness on the mechanical response of rock-like specimens with nonpersistent joints under uniaxial compression based on joint deformation analysis

Underground Space
Joint deformation is a key factor controlling the mechanical behavior of discontinuous rock strata under changing stress conditions, including dominating the elastic deformation in near-surface excavations and serving as a major component of settlement ...
Hong Yin, Zehui Gao, Yulong Shao, Shuhong Wang, Jae-Joon Song, Ye Wang, Jineon Kim, Shan Guo   +7 more
doaj   +1 more source

Influence of load interactions on crack growth as related to state of stress and crack closure [PDF]

Fatigue crack propagation (FCP) after an application of a low-high loading sequence was investigated as a function of specimen thickness and crack closure.
Telesman, J.
core   +1 more source

Short crack initiation and growth at 600 °C in notched specimens of Inconel718

, 2003
The natural initiation and growth of short cracks in Inconel®718 U-notch specimens has been studied at 600 °C in air. U notches were introduced through broaching, and hardness traces and optical microscopy on cross-sections through the U notch broaching ...
Connolley, T., Reed, P.A.S., Starink, M.J.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Propagation of Fatigue Cracks under Shear Loading Modes II, III and II+III in the Near-Threshold Region [PDF]

, 2014
Práce je zaměřena na šíření únavových trhlin v módech II, III a II + III v prahové oblasti v kovových materiálech. Byly provedeny experimenty pro ARMCO železo, titan, nikl a austenitickou ocel na třech druzích vzorků pro zatěžování trhliny ve smykových ...
Vojtek, Tomáš
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Modeling of creep-fatigue interaction effects on crack growth at elevated temperatures

MATEC Web of Conferences, 2018
The well-known load frequency effect on creep-fatigue crack growth is explained by the interactions between fatigue and creep loading and is quantified using the concept of plasticity-induced crack closure.
Potirniche Gabriel P.
doaj   +1 more source

2-D ELASTODYNAMIC PROBLEM FOR AN INTERFACE CRACK UNDER AN OBLIQUE HARMONIC LOADING [PDF]

, 2013
Acknowledgements The authors would like to acknowledge major financial support received from the College of the Physical Sciences of the University of Aberdeen and the Engineering and Physical Sciences Research Council ...
Menshykov, Oleksandr, Mikucka, Vita
core