Results 61 to 70 of about 58,593 (304)

Acoustic characterization of crack damage evolution in sandstone deformed under conventional and true triaxial loading [PDF]

, 2017
We thank the Associate Editor, Michelle Cooke, and the reviewers, Ze'ev Reches and Yves Guéguen, for useful comments which helped to improve the manuscript. We thank J.G.
Browning, J., Harland, S., Healy, D., Meredith, P. G., Mitchell, T. M., Stuart, C. E.   +5 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

3D-VCCT based fracture analysis method for gas pipelines with multiple cracks

Natural Gas Industry B, 2019
The current national criteria cannot accurately reflect the multi-crack interference effect of defective gas pipelines, and thus result in conservative assessment results.
Anlin Yao, Wenbo He, Taolong Xu, Hongye Jiang, Dongfang Gu   +4 more
doaj   +1 more source

Correlation between the pivot node concept and fatigue crack closure [PDF]

, 2018
The study of fatigue crack growth has been commonly done by means of bi-dimensional models and assuming a homogeneous behaviour through the thickness. According to the specimen thickness, a state of plane stress or plane strain is presumed.
Camas, Daniel, García-Manrique-Ocaña, José Manuel, Gozalez-Herrera, Antonio   +2 more
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Partial crack closure under block loading [PDF]

, 1980
Fatigue crack propagation tests under high-low and low-high block loading sequences have been performed in aluminium alloy specimens. The tests were carried out at constant [Delta]K conditions. Two stress ratios were analysed: R = 0.05 and R = 0.4. Crack
Borrego, L. P., Ferreira, J. M., Costa, J. M.   +2 more
core   +2 more sources

High cycle fatigue and ratcheting interaction of laser powder bed fusion stainless steel 316L:Fracture behaviour and stress-based modelling [PDF]

, 2018
Variations in the physical and mechanical properties of parts made by laser power bed fusion (L-PBF) could be affected by the choice of processing or post-processing strategies.
Hardacre, David, Li, Hua, Sun, Chen-Nan, Wei, Jun, Zhang, Meng, Zhang, Xiang   +5 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Fatigue life prediction of z-fibre pinned composite laminate under mode I loading [PDF]

, 2019
A hybrid method is presented combining linear elastic fracture mechanics with nonlinear damage mechanics that can predict the fatigue crack growth rate in z-fibre pinned composites under mode I loading.
Ayre, David, Lemanski, Stuart, Tang, Suchao, Zhang, Xiang   +3 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source