Results 81 to 90 of about 58,593 (304)
A study of fatigue crack closure using electric potential and compliance techniques [PDF]
Compared are closure data produced on the same specimen by the crack tip compliance gage and electric potential techniques. Experiments on 7075-T651 aluminum center cracked panels produced equivalent results on closure using the two techniques.
Cassatt, G. C., Clarke, C. K.
core +1 more source
Fatigue crack growth in a particulate TiB2 reinforced powder metallurgy iron-based composite
, 2003 Fatigue crack growth behavior has been examined in a particulate titanium diboride (TiB2)–reinforced iron-based composite that had been produced via a mechanical alloying process.
Sinclair, I., Yang, N.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Journal of Materials Research and Technology, 2019 This paper presents the thermo-elastic effect on materials having anisotropic behavior and stresses developed due to residual temperature on interlaminar delamination fracture characteristics of composite skin stiffener.
Saumya Shah +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Strain-energy release rate analysis of a laminate with a postbuckled delamination [PDF]
The objectives are to present the derivation of the new virtual crack closure technique, evaluate the accuracy of the technique, and finally to present the results of a limited parametric study of laminates with a postbuckled delamination.
Shivakumar, K. N., Whitcomb, John D.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Environmental fatigue in aluminum-lithium alloys [PDF]
Aluminum-lithium alloys exhibit similar environmental fatigue crack growth characteristics compared to conventional 2000 series alloys and are more resistant to environmental fatigue compared to 7000 series alloys.
Piascik, Robert S.
core +1 more source
Characterization of Microstructural Effects on Fatigue Crack Closure
, 1991 The growth of a fatigue crack is modified by the development of contacts between the crack faces1,2 creating shielding and thus canceling a portion of the applied load. These contacts develop through a number of mechanisms, including plastic deformation, sliding of the faces with respect to each other and the creation and collection of debris such as ...
Rehbein, David, Barnard, Dan, Buck, Otto
openaire +3 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source