Results 91 to 100 of about 1,354,072 (296)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

High temperature effects on fatigue performance and crack initiation mechanisms of 316LN stainless steel for nuclear power pipelines

Journal of Materials Research and Technology
This study performed high-cycle fatigue tests on 316LN stainless steel (SS) for nuclear power application to evaluate its fatigue behavior at both room temperature (RT) and 350 °C.
JianNeng Zheng, JunChao Hu, YueHui Jiang, QingYuan Wang, Kun Yang   +4 more
doaj   +1 more source

Dynamic fracture of soda-lime glass: A full-field optical investigation of crack initiation, propagation and branching

Journal of the mechanics and physics of solids, 2018
Dynamic crack initiation, growth and branching phenomena are comprehensively investigated in soda-lime glass using a vision-based method, Digital Gradient Sensing (DGS), in conjunction with digital ultrahigh-speed photography.
B. Sundaram, H. Tippur
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Stress corrosion crack initiation in machined type 316L austenitic stainless steel in simulated pressurized water reactor primary water

Corrosion Science, 2018
The effect of machining on stress corrosion crack initiation of annealed Type 316L stainless steel was investigated through accelerated testing in high-temperature hydrogenated water.
Litao Chang, M. G. Burke, F. Scenini
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Strain accumulation and fatigue crack initiation at pores and carbides in a SX superalloy at room temperature

International Journal of Fatigue, 2018
Pores and carbides inherited from SX superalloy manufacturing processes usually act as stress concentrators and are preferential sites for fatigue crack initiation.
R. Jiang, D. Bull, A. Evangelou, A. Harte, F. Pierron, I. Sinclair, M. Preuss, X. Hu, P. Reed   +8 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Crack Initiation and Propagation Fatigue Life of Ultra High-Strength Steel Butt Joints

Applied Sciences, 2019
The division of the total fatigue life into different stages such as crack initiation and propagation is an important issue in regard to an improved fatigue assessment especially for high-strength welded joints.
Markus J. Ottersböck, Martin Leitner, Michael Stoschka, Wilhelm Maurer   +3 more
doaj   +1 more source

Transition from internal to surface crack initiation of a single-crystal superalloy in the very-high-cycle fatigue regime at 1100 °C

, 2021
Zihua Zhao, Q. Li, F. Zhang, W. Xu, Bo Chen   +4 more
semanticscholar   +1 more source