Results 41 to 50 of about 1,354,072 (296)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
矿业科学学报This study aims to investigate the crack propagation mechanism of directional hydraulic fracturing of coal mine roof and explore the relationship between fracture criteria.
HOU Gongyu +5 more
doaj +1 more source
Metals, 2022 The impact toughness of a high-strength metastable β titanium alloy (Ti-5Cr-4Al-4Zr-3Mo-2W-0.8Fe) with two typical microstructures is studied by Charpy impact tests. The bimodal microstructure (BM) and the lamellar microstructure (LM) are obtained by the
Jing Wang +5 more
doaj +1 more source
Acta Materialia, 2019 Localized deformation has emerged as a key factor in the crack initiation process for irradiated steels, as cracks are observed to nucleate preferentially at these sites.
D. C. Johnson +3 more
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Applied Mathematical Modelling, 2019 To solve the fatigue crack initiation problem, it is necessary to calculate the fatigue crack initiation size. According to the aspect of macroscopic crack development, the calculation method of crack initiation size is determined by the critical ...
Haijie Wang +3 more
semanticscholar +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Initiation of internal fatigue crack in a carbide-free bainitic steel during high cycle fatigue
Journal of Materials Research and TechnologyThe crack initiation stage is crucial to the overall fatigue behavior of the carbide-free bainitic steels. Through S–N curve testing and fracture observation, it is demonstrated that internal crack initiation is the dominant mode during high cycle ...
Bo Mi +5 more
doaj +1 more source
Modelling crack initiation in bituminous binders under a rotational shear fatigue load
, 2020 This study aims to model fatigue crack initiation in bituminous binders. An energy-based crack initiation criterion is developed for bitumen under a rotational shear fatigue load.
Yangming Gao, Linglin Li, Yuqing Zhang
semanticscholar +1 more source