Results 51 to 60 of about 1,354,072 (296)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Jixie qiangdu, 2020 The fatigue crack initiation of the fuselage structure skin under the uniform supercharged cyclic load of 0 ～ 7. 8 Psi was experimentally studied by the self-made aircraft fuselage skin uniform supercharged fatigue simulation device.
LIU LiPing +5 more
doaj
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Applied SciencesThe development of hot dry rock needs working fluids, and mineral reactions happen due to contact between hot dry rock minerals and fluids. Mineral reactions influence hot dry rock reservoir characteristics, whereas their impacts on hot dry rock ...
Ou Jiang +4 more
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International Journal of Fatigue, 2019 Microstructural cyclic deformation mechanisms and their relation to small fatigue crack initiation and early propagation behavior were experimentally investigated in a rare earth-containing magnesium alloy (Mg-Gd-Y-Zr).
Chao He +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Cracking Mode Analysis of Crack Initiation in Rocks under Uniaxial Compression
Advances in Civil Engineering, 2019 Crack initiation is related to the behavior of the preexisting microcracks within a rock specimen, which suggests the specimen starts to fail. The determination of crack initiation stress is important for identifying the elastic stage and related ...
Ye Lou, Guangqing Zhang, Xiaoxiao Wang
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Onset of Crack Initiation in Uniaxial and Triaxial Compression Tests of Dolomite Samples
Studia Geotechnica et Mechanica, 2014 The paper presents results of laboratory investigation and analysis of crack initiation threshold identification of dolomite samples. First, selected methods for determining crack initiation thresholds are briefly described with special attention paid to
Cieślik Jerzy
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Shock and Vibration, 2021 The purpose of this paper is to study the crack initiation, propagation, and coalescence of the sandy mudstone sample with two sets of prefabricated cross-flaws under uniaxial compression.
Dongxu Liang +3 more
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