Results 101 to 110 of about 4,014,681 (349)
The post-yield fracture of a ductile polymer film: Notch quality, essential work of fracture, crack tip opening displacement, and J-integral [PDF]
, 2017 Double edge notched tension (DENT) specimens of a polyethylene terephthalate (PET) film were tested in an universal testing machine, measuring the displacements and the ligament lengths with a digital image correlation (DIC) system.
Arencón Osuna, David +3 more
core +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Micro-mechanical analysis of damage growth and fracture in discontinuous fiber reinforced metal matrix composites [PDF]
The near-crack-tip stresses in any planar coupon of arbitrary geometry subjected to mode 1 loading may be equated to those in an infinite center-cracked panel subjected to the appropriate equivalent remote biaxial stresses (ERBS).
Goree, James G., Richardson, David E.
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Scientific ReportsThe biaxial compression experiments of rock-like materials with two flaws are carried out under different flaw inclination angle, rock bridge ligament angle, lateral stress. The experimental studies show that crack propagation modes of rock-like material
Shuailong Lian +4 more
doaj +1 more source
Finite element analyses of fatigue crack growth under small scale yielding conditions modelled with a cyclic cohesive zone approach [PDF]
, 2013 Mode I fatigue crack growth is modelled and investigated with a cohesive zone approach. A 2D finite element boundary layer model under plane strain and small scale yielding conditions is used to generate fatigue crack growth rate curves ...
Kuna, Meinhard, Roth, Stephan
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The effects of crack surface friction and roughness on crack tip stress fields [PDF]
A model is presented which can be used to incorporate the effects of friction and tortuosity along crack surfaces through a constitutive law applied to the interface between opposing crack surfaces.
Ballarini, Roberto, Plesha, Michael E.
core +1 more source
Peeling from a patterned thin elastic film
, 2004 Inspired by the observation that many naturally occurring adhesives arise as textured thin films, we consider the displacement controlled peeling of a flexible plate from an incision-patterned thin adhesive elastic layer.
Chaudhury, M. K. +4 more
core +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source