Results 111 to 120 of about 4,014,681 (349)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effects of crack tip geometry on dislocation emission and cleavage: A possible path to enhanced ductility

, 1996
We present a systematic study of the effect of crack blunting on subsequent crack propagation and dislocation emission. We show that the stress intensity factor required to propagate the crack is increased as the crack is blunted by up to thirteen atomic
%J. R. Rice, A. E. Carlsson, A. Paskin, A. S. Argon, C. E. Inglis, C. E. Inglis, D. B. Barts, E. B. Tadmor, E. Sternberg, G. E. Beltz, G. Schoeck, I.-H. Lin, J. H. Rose, J. R. Rice, J. Schiøtz, J. Schiøtz, L. M. Canel, L. M. Canel, L. P. Kubin, N. I. Muskhelishvili, P. Gumbsch, R. Thomson, R. Thomson, R. Thomson, S. D. Carothers, S. D. Mesarovic, S. J. Zhou, S. J. Zhou, S. J. Zhou, S. J. Zhou, S. J. Zhou, S. Kohlhoff, S. M. Ohr, S. P. Timoshenko, V. Shastry   +34 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Influence of Crack Modes on the Elastic Wave Propagation Characteristics in a Non-Uniform Rotating Shaft

Applied Sciences, 2018
The transverse crack in a non-uniform shaft possesses different crack modes, and it can affect the propagation characteristics of the elastic waves in the shaft.
Yimin Wei, Xuan Shi, Qi Liu, Wenhua Chen
doaj   +1 more source

Perilaku Retak Aluminium Paduan A6061-T6 Pada Pembebanan Mixed Mode [PDF]

, 2006
Fracture behavior of aluminum alloys (A6061-T6) under mixed mode (Mode I+II) loading was studied. Compact-tension-shear (CTS) specimen was employed and angle between loading axis and the crack surface was varied from 90°(mode I) to 0°(mode II). The crack
Husaini, H. (Husaini), Zuhaimi, Z. (Zuhaimi)   +1 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Finite element analysis of the ECT test on mode III interlaminar fracture of carbon-epoxy composite laminates [PDF]

, 2006
In this work a parametric study of the Edge Crack Torsion (ECT) specimen was performed in order to maximize the mode III component (GIII) of the strain energy release rate for carbon-epoxy laminates.
Morais, A. B. de, Morais, J. J. L., Moura, M. F. S. F. de, Silva, M. A. L.   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mixed mode stress intensity factors for semielliptical surface cracks [PDF]

The three-dimensional equations of elasticity are solved for a flat elliptical crack which has nonuniform shear stresses applied to its surfaces. An alternating method is used to determine the mode two and mode three stress intensity factors for a ...
Smith, F. W., Sorensen, D. R.
core   +1 more source