Results 61 to 70 of about 4,014,681 (349)

Mode I crack tip fields: strain gradient plasticity theory versus J2 flow theory

open access: yes, 2019
The mode I crack tip asymptotic response of a solid characterised by strain gradient plasticity is investigated. It is found that elastic strains dominate plastic strains near the crack tip, and thus the Cauchy stress and the strain state are given ...
Fleck, Norman A.   +1 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Crack Damage Identification of Pantograph Upper Frame Elbow Joint Based on Strain Mode

open access: yesChengshi guidao jiaotong yanjiu
ObjectiveThe structural safety of pantograph has a significant impact on the operational reliability of trains. Fatigue cracks are prone to occur at the elbow joints of pantograph on high-speed trains.
Haixiang GAO   +6 more
doaj   +1 more source

FRACTURE CRITERIA FOR COMBINED MODE CRACKS

open access: yes, 1978
The complex variable method is employed to analyse the energy release rate for combined mode cracks. A functional integral equation, which contains no singularity, is derived for a branched crack problem by a functional transformation. The integrand φ_1'(z) is expanded in eigenfunctions. The energy fracture criterion for the combined mode (K_Ⅰ and K_Ⅱ)
openaire   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Numerical study of crack path by MMCG specimen using M integral [PDF]

open access: yesFracture and Structural Integrity, 2016
The mixed mode loading configuration occurs in many civil engineering and mechanical applications. In wood material, the study of this problem is very important due to the orthotropic character and the heterogeneity of the material.
S. El Kabir   +4 more
doaj   +1 more source

Finite Element Analysis of FRP Debonding Failure at the Tip of Flexural/Shear Crack in Concrete Beam [PDF]

open access: yes, 2013
One of the most common failure modes of strengthened RC beams with externally bonded FRP is intermediate crack (IC) debonding of FRP initiated at the tip of flexural/shear cracks. This study presents a method, using extended finite element method (XFEM),
Harries, Kent   +2 more
core   +1 more source

Propagation of surface initiated rolling contact fatigue cracks in bearing Steel [PDF]

open access: yes, 2016
Surface initiated rolling contact fatigue, leading to a surface failure known as pitting, is a life limiting failure mode in many modern machine elements, particularly rolling element bearings.
Kadiric, A, Olver, A, Rycerz, P
core   +1 more source

MIXED-MODE CRACK GROWTH IN WOOD

open access: yesPro Ligno, 2012
In timber elements the mixed mode depends essentially of wood anatomy and load configuration.In these conditions, in order to evaluate the material behavior and the fracture process, it’s necessary to separate the part of each mode. The mixed mode separation allows evaluating the amplitude of fracture mode. In the present paper, using a mixedmode crack
Pop, Octavian   +2 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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