Results 81 to 90 of about 4,014,681 (349)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Composite interlaminar fracture toughness: Three-dimensional finite element modeling for mixed mode 1, 2 and 3 fracture [PDF]
A computational method/procedure is described which can be used to simulate individual and mixed mode interlaminar fracture progression in fiber composite laminates.
Chamis, C. C., Murthy, P. L. N.
core +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Interlaminar crack growth in fiber reinforced composites during fatigue, part 3 [PDF]
Interlaminar crack growth behavior in fiber-reinforced composites subjected to fatigue loading was investigated experimentally and theoretically. In the experimental phase, inter-laminar crack propagation rates and mechanisms were determined for the ...
Wang, H. T., Wang, S. S.
core +1 more source
Fatigue crack propagation in microcapsule toughened epoxy [PDF]
, 2004 The addition of liquid-filled urea-formaldehyde (UF) microcapsules to an epoxy matrix leads to significant reduction in fatigue crack growth rate and corresponding increase in fatigue life.
Brown, Eric N. +2 more
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Fracture and Structural Integrity, 2019 The purpose of this article is to present the stress intensity factors (SIF) solutions for semi-elliptic crack in pipelines under internal pressures, the stress intensity factors are calculated by the three-dimensional finite element method (FEM) for ...
Djamel Eddine Belhadri +3 more
doaj
An equivalent domain integral method for three-dimensional mixed-mode fracture problems [PDF]
A general formulation of the equivalent domain integral (EDI) method for mixed mode fracture problems in cracked solids is presented. The method is discussed in the context of a 3-D finite element analysis.
Raju, I. S., Shivakumar, K. N.
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source