Results 71 to 80 of about 66,884 (287)

Fracture properties of dolomite and prediction of fracture toughness based on BP-ANN

open access: yesScientific Reports
In this study, based on the digital image correlation technique, three-point bending tests were conducted on dolomite semi-circular bending (SCB) specimens, and the fracture properties of the SCB specimens, including crack opening displacement, apparent ...
Yu Guo   +4 more
doaj   +1 more source

Establishing the fiber bridging law by an inverse analysis approach [PDF]

open access: yes, 2016
A method for establishing the relationship between stress and crack face opening for steel fiber–reinforced concrete (SFRC) beams under three-point loading was proposed using inverse analysis.
Karadelis, John N., Lin, Y.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

A phase-field model for cohesive fracture [PDF]

open access: yes, 2013
In this paper, a phase-field model for cohesive fracture is developed. After casting the cohesive zone approach in an energetic framework, which is suitable for incorporation in phase-field approaches, the phase-field approach to brittle fracture is ...
Auricchio   +29 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Elevated temperature crack growth [PDF]

open access: yes
Alloy 718 crack growth experiments were conducted to assess the ability of the selected path-independent (P-I) integrals to describe the elevated temperature crack growth behavior.
Kim, K. S., Vanstone, R. H.
core   +4 more sources

Determination of fracture mechanics parameters by digital image correlation method of surface crack for 7075 Al alloy under nonproportional cyclic loading (Growth life prediction method considering shear stress on the crack surface)

open access: yesNihon Kikai Gakkai ronbunshu
A method for predicting the propagation life of a crack initiated on the surface of a 7075 aluminum alloy under nonproportional loading was proposed using the modified Paris law.
Yuichi ONO, Kaito WATANABE, Nao KANEKO
doaj   +1 more source

Stress analysis and stress intensity factors for finite geometry solids containing rectangular surface cracks [PDF]

open access: yes
The line method of analysis is applied to the Navier-Cauchy equations of elastic equilibrium to calculate the displacement field in a finite geometry bar containing a variable depth rectangular surface crack under extensionally applied uniform loading ...
Gyekenyesi, J. P., Mendelson, A.
core   +1 more source

Cohesive zone models in history dependent materials [PDF]

open access: yes, 2013
Copyright @ 2013 ACMECohesive zone model is a well known concept in nonlinear fracture mechanics of elasto-plastic materials. In contrast to that, we discuss a development of the cohesive zone model to linear, but time and history dependent, materials ...
Hakim, L, Mikhailov, SE
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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