Results 91 to 100 of about 403,344 (296)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Calculation of crack width and crack spacing [Elektronisk resurs]

, 2007
The present paper discusses crack propagation and special attention is given to how the combined effect of reinforcement and fibre bridging influences the crack spacing and width in the serviceability limit state.
Lövgren, Ingemar,
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Experimental and Analytical Investigation of Crack Spacing and Width for Overlaid RC Beams at Elevated Temperatures [PDF]

, 2017
Cracking in overlay-strengthened RC structures significantly influences their structural performance; however, the effect of elevated temperatures on cracking behavior remains unclear.
Dawei Zhang, Wang, Bo, Zhang, Dawei, Tamon Ueda, Bo Wang, Rashid, Khuram, Khuram Rashid, Ueda, Tamon   +7 more
core   +1 more source

Study on Chloride Ion Diffusion Model in Crack Zones of Saturated Concrete Structure

Zhongwai Gonglu
In order to accurately characterize the behavior of cracks in accelerating chloride ion transport on both sides of the concrete, the concept of effective influence distance of cracks was proposed, and the crack pores were non-uniformly distributed ...
PENG Jianxin, ZHOU Pengcheng, CHENG Xiaokang, ZHOU Yadong   +3 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Effects of bedding characteristics on crack propagation of coal under mode II loading: Laboratory experiment and numerical simulation

Journal of Rock Mechanics and Geotechnical Engineering
The fracture network of hydraulic crack is significantly influenced by the bedding plane in coalbed methane extraction. Under mode II loading, crack deflection holds a key position in hydraulic cracking, especially in hydraulic shearing. This study first
Zhuang Sun, Yixin Zhao, Yirui Gao, Xiaoliang Wang, Hao Wang, Bin Liu, Yaodong Jiang   +6 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Text spacing considerations for children’s on-screen reading [PDF]

, 2008
This investigation seeks to uncover the insights of three integral and inter-related participants in the creation and use of on-screen reading material for children’s learning.
Vanderschantz, Nicholas, Nicholas Vanderschantz   +1 more
core