Results 101 to 110 of about 403,344 (296)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The effect of offset distance on dynamic fracture behavior of PMMA with double cracks

矿业科学学报, 2017
The influence of offset crack on dynamic impact fracture behavior is studied using the digital-leaser dynamic caustics system in conjunction with impact loading device.
Yang Liyun, Zhang Yongjin, Sun Jinchao, Liu Ning, Cheng Tonglei, Chen Qifan   +5 more
doaj  

A methodology for evaluating the fracture width of a notched RC multiple-layer flat slab under cyclic loading

MethodsX
This paper introduces an innovative method for assessing crack width in notched reinforced concrete (RC) slabs under cyclic loads, considering both precast and in-situ layers in composite slab configurations.
Nawir Rasidi, Taufiq Rochman
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Development of a Manual Crack Quantification and Automated Crack Measurment System, Project TR-457 Final Report, 2005 [PDF]

, 2005
Final report produced by DOT on development of manual crack quantification and automatic crack measurment ...

core  

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Study on coalescence criterion of double elliptic cracks in finite homogeneous plates under the uniaxial tensile load based on GTN model

Jixie qiangdu
Based on the Gurson-Tvergaard-Needleman (GTN) damage model, the coalescence behavior of double elliptical cracks with different sizes and the coalescence criterion based on crack spacing ratio was studied in homogeneous plates with elliptical double ...
LIU Hongxia, CUI Yuanyuan, WANG Xiaoxiao, LIU Fang, YANG Jie, CHEN Haofeng   +5 more
doaj  

Influence of Slot Angle and Hole Spacing on Directional Crack Propagation in Sandstone with V-Shaped Slotted Blastholes

Applied Sciences
To improve the directional propagation of blasting-induced cracks in sandstone and reduce over-excavation, under-excavation, and surrounding-rock damage caused by conventional circular blastholes, circular and V-shaped slotted blasthole models were ...
Bin Zhang, Jianlin Li, Yao Li, Zijian Huang, Xuefu Zhang, Xiaogang Li, Peng Ding   +6 more
doaj   +1 more source