Results 61 to 70 of about 71,955 (280)
Shear strength and cracking behavior of reinforced concrete nonstructural walls
Journal of Asian Architecture and Building Engineering, 2022 Recent Japanese earthquakes have severely damaged the nonstructural walls of many buildings. While nonstructural walls do not influence the seismic performance of a building, this damage can still sometimes cause buildings to be demolished or render ...
Miki Matsubayashi +2 more
doaj +1 more source
The Cracking and Tensile-Load-Bearing Behaviour of Concrete Reinforced with Sanded Carbon Grids
Buildings, 2023 This article presents the cracking and load-bearing behaviour of carbon-reinforced prismatic concrete tensile specimens. Grids with different geometries and impregnations were used as carbon reinforcement.
Michael Frenzel +3 more
doaj +1 more source
Development and geometry of isotropic and directional shrinkage crack patterns
, 1999 We have studied shrinkage crack patterns which form when a thin layer of an alumina/water slurry dries. Both isotropic and directional drying were studied.
A. A. Griffiths +36 more
core +1 more source
Simple models of the hydrofracture process [PDF]
, 2015 Hydrofracturing to recover natural gas and oil relies on the creation of a fracture network with pressurized water. We analyze the creation of the network in two ways.
Chen, Chih Hung, Marder, M., Patzek, T.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Advances in Civil Engineering, 2020 In order to explore the reasonable spacing of charge holes in empty-hole directional blasting, based on the action mechanism of empty-hole directional blasting, the influence of charge hole spacing on crack propagation is studied, the calculation formula
Guobin Tian +4 more
doaj +1 more source
Studies of cracking behavior in melt-processed YBCO bulk superconductors [PDF]
, 2006 An important phenomenon in bulk superconductors fabricated by top-seeded-melt growth (TSMG) is the formation of cracks due to the inherent brittleness of the YBa2Cu3O7-δ (Y-123) phase matrix.
S Haindl +15 more
core +1 more source