Results 31 to 40 of about 73,733 (293)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Multiparametric presentation of the crack-tip fields in the vicinity of longitudinal shear crack

Вестник Самарского университета: Естественнонаучная серия
The article is devoted to the study of the stress field at the tip of a longitudinal shear crack based on a multiparametric asymptotic representation of the stress field at the crack tip in a linearly elastic isotropic material.
Yulia N. Bakhareva
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Breakdown of Linear Elastic Fracture Mechanics near the Tip of a Rapid Crack

, 2008
We present high resolution measurements of the displacement and strain fields near the tip of a dynamic (Mode I) crack. The experiments are performed on polyacrylamide gels, brittle elastomers whose fracture dynamics mirror those of typical brittle ...
Ariel Livne, E. Bouchbinder, Eran Bouchbinder, Jay Fineberg, K. Ravi-Chandar, L. B. Freund   +5 more
core   +1 more source

Identification and prediction of mixed-mode fatigue crack path in high strength low Alloy steel [PDF]

, 2018
The trajectory of fatigue crack growth is influenced by many parameters and can be irregular due to changes in stress distribution or in material properties as the crack progresses.
De Waele, Wim, Hertelé, Stijn, Kiekens, Cedric, Zhang, Jie   +3 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Frictional interface crack-tip singular stress field in anisotropic [PDF]

, 2013
This study presents the asymptotic displacement and stress fields at the crack tip of frictional interface where slip can occur along the interface between two anisotropic composite laminates.
Chen, Hua-Peng
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Comparison of the constraint parameters in elastic-plastic fracture mechanics Focused on Crack Tip Fields

Fracture and Structural Integrity, 2019
To describe the effect of crack-tip constraint on the stress field for finite cracked bodies, the following most widely used constraint parameters can be employed in elastic-plastic fracture mechanics, namely, local triaxiality parameter, constraint ...
Yu. G. Matvienko
doaj   +1 more source