Results 101 to 110 of about 636,508 (285)
Experimental study of surface cracks [PDF]
, 1972 Analysis of plastic zones surrounding surface cracks in stressed steel and titanium plates subjected to tensile loading shows that back surface dimpling develops at stress levels considerably lower than those predicted by theoretical models of yield zone
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Self-healing of concrete cracks by the release of embedded water repellent agents and corrosion inhibitors to reduce the risk for reinforcement corrosion [PDF]
, 2017 From the worldwide steel production, approximately 50 per cent is required to replace corroded steel [1]. In the case of reinforced concrete structures, corrosion of the reinforcement steel causes crack formation and spalling which leads to ...
De Belie, Nele +5 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Test program to provide confidence in liquid oxygen cooling of hydrocarbon fueled rocket thrust chambers [PDF]
An experimental program has been planned at the NASA Lewis Research Center to build confidence in the feasibility of liquid oxygen cooling for hydrocarbon fueled rocket engines.
Armstrong, E. S.
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Experimental analysis of the fatigue life of threaded pipe connections under cyclic bending [PDF]
, 2012 When subjected to cyclic loads, fatigue cracks can cause failure of pipe systems joined by threaded pipe connections. In this study, the effect of contact conditions and coupling geometry is investigated experimentally. Fatigue tests under cyclic bending
De Baets, PatrickTW08TW51TW568010007297790000-0002-0552-3850F46EAEFE-F0ED-11E1-A9DE-61C894A0A6B4 +4 more
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