Results 21 to 30 of about 332,672 (384)

Quantification of Fetal Renal Function Using Fetal Urine Production Rate and Its Reflection on the Amniotic and Fetal Creatinine Levels During Pregnancy

Frontiers in Pediatrics, 2022
Adequate prediction of fetal exposure of drugs excreted by the kidney requires the incorporation of time-varying renal function parameters into a pharmacokinetic model. Published data on measurements of fetal urinary production rate (FUPR) and creatinine
Udoamaka Ezuruike, Alexander Blenkinsop, Amita Pansari, Khaled Abduljalil   +3 more
doaj   +1 more source

Creatine Metabolism in Female Reproduction, Pregnancy and Newborn Health

Nutrients, 2021
Creatine metabolism is an important component of cellular energy homeostasis. Via the creatine kinase circuit, creatine derived from our diet or synthesized endogenously provides spatial and temporal maintenance of intracellular adenosine triphosphate ...
A. M. Muccini, N. Tran, D. D. de Guingand, Mamatha Philip, Paul A Della Gatta, R. Galinsky, L. Sherman, Meredith A. Kelleher, K. Palmer, M. Berry, D. Walker, R. Snow, S. Ellery   +12 more
semanticscholar   +1 more source

Role of Creatine in the Heart: Health and Disease

Nutrients, 2021
Creatine is a key player in heart contraction and energy metabolism. Creatine supplementation (throughout the paper, only supplementation with creatine monohydrate will be reviewed, as this is by far the most used and best-known way of supplementing ...
M. Balestrino
semanticscholar   +1 more source

Meta-Analysis Examining the Importance of Creatine Ingestion Strategies on Lean Tissue Mass and Strength in Older Adults

Nutrients, 2021
Creatine supplementation in conjunction with resistance training (RT) augments gains in lean tissue mass and strength in aging adults; however, there is a large amount of heterogeneity between individual studies that may be related to creatine ingestion ...
Scott C. Forbes, D. Candow, S. Ostojić, M. Roberts, P. Chilibeck   +4 more
semanticscholar   +1 more source

Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels

Science Advances, 2021
RGX-202, a small-molecule creatine transporter SLC6A8 inhibitor, suppresses colorectal cancer and modulates human creatine levels.
I. Kurth, N. Yamaguchi, Celia Andreu-Agullo, Helen S Tian, S. Sridhar, Shugaku Takeda, Foster C. Gonsalves, J. Loo, A. Barlas, K. Manova-Todorova, R. Busby, J. Bendell, J. Strauss, M. Fakih, A. McRee, A. Hendifar, L. Rosen, A. Cercek, R. Wasserman, M. Szarek, S. Spector, S. Raza, M. Tavazoie, S. Tavazoie   +23 more
semanticscholar   +1 more source

Tumour‐derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8‐mediated creatine import in NPM1‐mutated acute myeloid leukaemia

Journal of Extracellular Vesicles, 2021
Acute myeloid leukaemia (AML) carrying nucleophosmin (NPM1) mutations has been defined as a distinct entity of acute leukaemia. Despite remarkable improvements in diagnosis and treatment, the long‐term outcomes for this entity remain unsatisfactory ...
Meixi Peng, Jun Ren, Yipei Jing, Xueke Jiang, Qiaoling Xiao, Junpeng Huang, Yonghong Tao, Li Lei, Xin Wang, Zailin Yang, Zesong Yang, Qian Zhan, Can Lin, Guoxiang Jin, Xian Zhang, Ling Zhang   +15 more
doaj   +1 more source

Perspective: Creatine, a Conditionally Essential Nutrient: Building the Case.

Advances in Nutrition, 2021
Creatine is a major component of energy metabolism that is abundant in human skeletal muscle, brain, and heart. Either synthesized internally or provided via an omnivorous diet, creatine is required for normal growth, development, and health.
S. Ostojić, Scott C. Forbes
semanticscholar   +1 more source

Historical data on cardiovascular health in Surinamese men

BMC Research Notes, 2018
Objectives Cardiovascular risk factor burden was recently reported to be high in the Caribbean country Suriname. However, historical data for comparison were lacking.
Lizzy M. Brewster, Jules Brewster
doaj   +1 more source

Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

Frontiers in Neuroscience, 2020
Glutamate detection in pons and thalamus using proton magnetic resonance spectroscopy (1H-MRS) after an intervention is of interest for studying various brain disorders. However, 1H-MRS in these brain regions is challenging and time-consuming, especially
Samaira Younis, Anders Hougaard, Casper E. Christensen, Mark B. Vestergaard, Esben T. Petersen, Esben T. Petersen, Vincent O. Boer, Olaf B. Paulson, Messoud Ashina, Anouk Marsman, Henrik B. W. Larsson   +10 more
doaj   +1 more source

Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia

Frontiers in Physiology, 2021
Objective: Chronic hypoxia induces pulmonary and cardiovascular pathologies, including pulmonary hypertension (PH). L-arginine:glycine amidinotransferase (AGAT) is essential for homoarginine (hArg) and guanidinoacetate synthesis, the latter being ...
Juliane Hannemann, Juliane Hannemann, Kathrin Cordts, Anika Seniuk, Anika Seniuk, Chi-un Choe, Lena Schmidt-Hutten, Jorge Duque Escobar, Jorge Duque Escobar, Florian Weinberger, Rainer Böger, Rainer Böger, Rainer Böger, Edzard Schwedhelm, Edzard Schwedhelm   +14 more
doaj   +1 more source