Results 51 to 60 of about 255,253 (296)

The Role of Creatine Supplementation in Cardiovascular Health: A Comprehensive Review

Quality in Sport
Background Creatine is a compound synthesized in the human body, but it can also be obtained from food sources. Research demonstrates that creatine supplementation is safe, provides long-term benefits, and has therapeutic potential.
Aleksandra Owczarska, Julia Dołęga, Piotr Mól, Hubert Dacyl, Martyna Laskowska, Michał Pasiut, Barbara Lew   +6 more
doaj   +1 more source

On the role of the oxidation in the methylation of guanidoacetic acid [PDF]

, 1947
There are two, at least, methyl transfer reactions promoted by liver slices in vitro (2).
Borsook, Henry, Dubnoff, Jacob W.
core  

TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara, Naoki Kihara, Satoko Miyatake, Koji Fujita, Konoka Tachibana, Ryosuke Miyamoto, Hiroki Yamazaki, Yusuke Osaki, Nazere Keyoumu, Yuki Kuwano, Nobutoshi Morimoto, Suzuran Saito, Eriko Koshimizu, Yoichi Otomi, Kenji Ishibashi, Masafumi Harada, Naomichi Matsumoto, Hiroyuki Morino, Yuishin Izumi   +18 more
wiley   +1 more source

Creatine for the Treatment of Depression

Biomolecules, 2019
Depressed mood, which can occur in the context of major depressive disorder, bipolar disorder, and other conditions, represents a serious threat to public health and wellness.
Brent M. Kious, Douglas G. Kondo, Perry F. Renshaw   +2 more
doaj   +1 more source

Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients

Frontiers in Psychiatry, 2020
The glutamatergic system has previously been shown to be involved in the pathophysiology of schizophrenia and the mechanisms of action of antipsychotic treatment.
Jinguang Li, Jinguang Li, Honghong Ren, Ying He, ZongChang Li, Xiaoqian Ma, Liu Yuan, Lijun Ouyang, Jun Zhou, Dong Wang, Chunwang Li, Xiaogang Chen, Hongying Han, Jinsong Tang, Jinsong Tang   +14 more
doaj   +1 more source

³¹P Saturation Transfer and Phosphocreatine Imaging in the Monkey Brain [PDF]

, 1991
³¹P magnetic resonance imaging with chemical-shift discrimination by selective excitation has been employed to determine the phosphocreatine (PCr) distribution in the brains of three juvenile macaque monkeys.
Allman, John, Barker, Peter B., Mora, Bassem, Narasimhan, P. T., Ross, Brian D.   +4 more
core   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Low-Dosage Rumen Unprotected Creatine Precursor During the Transition Period in Single-Bearing Ewes Impacts Dynamic Changes in Muscle and Adipose Mass, Uterine Involution, and Fetal Programming Outcomes

Veterinary Sciences
Little is known about the reproductive impacts of the GAA, creatine precursor, in ruminants. This study aimed to evaluate the effects of GAA supply during the transition period in ewes with single pregnancies on their uterine involution.
Larissa Fernandes Baia Cesar, Alfredo José Herrera Conde, Camila Muniz Cavalcanti, Bruna Vitória de Freitas Alves, Marta da Costa Sousa, Jhennyfe Nobre de Sena, Yohana Huicho Miguel, Fernando Felipe da Silva Pereira, Louhanna Pinheiro Rodrigues Teixeira, Juliana Paula Martins Alves, César Carneiro Linhares Fernandes, Aníbal Coutinho do Rêgo, Dárcio Ítalo Alves Teixeira, Davide Rondina   +13 more
doaj   +1 more source

The Renal Activity Index for Lupus Identifies Active Renal Disease and Treatment Response in Adult Patients With Systemic Lupus Erythematosus and Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective We evaluated the ability of the Renal Activity Index for Lupus (RAIL) to discriminate active lupus nephritis (LN) in adult patients with active systemic lupus erythematosus (SLE) and differentiate LN treatment response. Methods Urine samples from adults with biopsy‐proven active class III and IV LN from TULIP‐LN (active LN group ...
Hermine I. Brunner, Ellen M. Cody, Prasad Devarajan, Bin Huang, Chen Chen, Dominic Sinibaldi, Madhu Ramaswamy, Jacob Knagenhjelm, Frederick Jones, Philip Z. Brohawn, Raj Tummala, Catharina Lindholm, Wendy I. White   +12 more
wiley   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology
Squamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor‐initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
doaj   +1 more source