Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity
Nature Metabolism, 2019 Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis reduces thermogenesis and causes obesity. However, whether creatine import from the circulation affects adipocyte thermogenesis is unknown. Here we show that deletion
L. Kazak +15 more
semanticscholar +1 more source
The role of supplementation in traumatic brain injury among athletes and non-athletes population
Quality in SportIntroduction: Traumatic brain injury (TBI) is one of the most common causes of death and long-term disability. The consequences following TBI can be persistent and cause life-long implications for survivors.
Sandra Agnieszka Pilawska +9 more
doaj +1 more source
¹³C NMR metabolomics: applications at natural abundance. [PDF]
, 2014 (13)C NMR has many advantages for a metabolomics study, including a large spectral dispersion, narrow singlets at natural abundance, and a direct measure of the backbone structures of metabolites.
Clendinen, Chaevien +7 more
core +3 more sources
The Evolving Applications of Creatine Supplementation: Could Creatine Improve Vascular Health?
Nutrients, 2020 Creatine is a naturally occurring compound, functioning in conjunction with creatine kinase to play a quintessential role in both cellular energy provision and intracellular energy shuttling.
H. Clarke +4 more
semanticscholar +1 more source
Creatine supplementation: facts and myths
Quality in SportIntroduction: Creatine (N-methylguanidinoacetic acid) is a peptide built of three amino acids: glycine, arginine and methionine. Its function is to store energy. It is common practice to intake creatine as a dietary supplement.
Weronika Kawecka +5 more
doaj +1 more source
Methionine formation by transmethylation in vitro [PDF]
, 1947 We reported in a previous communication (1) that guanidoacetic acid is methylated to creatine by rat liver slices in the presence of choline and either homocysteine or homocystine.
Borsook, Henry, Dubnoff, Jacob W.
core
Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training [PDF]
, 2010 Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase ...
Baguet, Audrey +3 more
core +2 more sources
Ketogenic Diet Plus Resistance Training Applied to Physio-Pathological Conditions: A Brief Review
Applied SciencesThe ketogenic diet (KD) is a nutritional strategy characterized by a reduced intake of carbohydrates (between 30 and 45 g per day or ≈5% of one’s total calories from this macronutrient).
Roberto Cannataro +6 more
doaj +1 more source
The formation of glycocyamine in animal tissues [PDF]
, 1941 It was shown in preceding communications that glycocyamine is converted into creatine by surviving liver slices (1). Our findings indicated that the methylating agent is methionine or a derivative of methionine.
Borsook, Henry, Dubnoff, Jacob W.
core
Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation. [PDF]
, 2019 The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasomes regulatory particle, consisting of lid
Aufderheide +42 more
core +1 more source