Results 71 to 80 of about 332,672 (384)

In-ovo feeding with creatine monohydrate: implications for chicken energy reserves and breast muscle development during the pre-post hatching period

Frontiers in Physiology, 2023
The most dynamic period throughout the lifespan of broiler chickens is the pre-post-hatching period, entailing profound effects on their energy status, survival rate, body weight, and muscle growth.
Jonathan Dayan, Tal Melkman-Zehavi, Noam Goldman, Francesca Soglia, Marco Zampiga, Massimiliano Petracci, Federico Sirri, Ulrike Braun, Vivienne Inhuber, Orna Halevy, Zehava Uni   +10 more
doaj   +1 more source

Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists [PDF]

, 2012
Background It has been shown that supplementation with creatine (Cr) and glycerol (Gly), when combined with glucose (Glu) necessary for the enhancement of Cr uptake by skeletal muscle, induces significant improvements in thermoregulatory and ...
Hambly, C., Lee, W.C., Malkova, D., Pantazis, T., Pitsiladis, Y.P., Polyviou, T.P., Speakman, J.R.   +6 more
core   +2 more sources

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Nature Metabolism, 2019
Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis reduces thermogenesis and causes obesity. However, whether creatine import from the circulation affects adipocyte thermogenesis is unknown. Here we show that deletion
L. Kazak, Janane F. Rahbani, B. Samborska, Gina Z. Lu, Mark P. Jedrychowski, Mathieu Lajoie, Song Zhang, L. Ramsay, Florence Y. Dou, Danielle E. Tenen, Edward T. Chouchani, P. Dzeja, I. Watson, Linus T. Tsai, E. Rosen, B. Spiegelman   +15 more
semanticscholar   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Methionine formation by transmethylation in vitro [PDF]

, 1947
We reported in a previous communication (1) that guanidoacetic acid is methylated to creatine by rat liver slices in the presence of choline and either homocysteine or homocystine.
Borsook, Henry, Dubnoff, Jacob W.
core  

Creatine kinase in energy metabolic signaling in muscle [PDF]

, 2007
There has been much debate on the mechanism of regulation of mitochondrial ATP synthesis to balance ATP consumption during changing cardiac workloads. A key role of creatine kinase (CK) isoenzymes in this regulation of oxidative phosphorylation and in ...
Johannes H. G. M. van Beek, Olav Kongas
core   +2 more sources

The Evolving Applications of Creatine Supplementation: Could Creatine Improve Vascular Health?

Nutrients, 2020
Creatine is a naturally occurring compound, functioning in conjunction with creatine kinase to play a quintessential role in both cellular energy provision and intracellular energy shuttling.
H. Clarke, Do-Houn Kim, Cesar A Meza, M. Ormsbee, R. Hickner   +4 more
semanticscholar   +1 more source

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

The hydrolysis of phosphocreatine and the origin of urinary creatinine [PDF]

, 1947
Shaffer (1), Myers and Fine (2), and Hahn and Meyer (3) adduced evidence that muscle creatine is the precursor of urinary creatinine. This was questioned by Chanutin and Kinard (4) but was conclusively proved by Bloch, Schoenheimer, and Rittenberg (5, 6)
Borsook, Henry, Dubnoff, Jacob W.
core  

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source