Results 161 to 170 of about 169,068 (339)

Mapping protein–protein interactions by mass spectrometry

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu   +4 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

A Mediterranean Diet‐Based Food Mix Ameliorates Diabetes‐ and Obesity‐Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming

open access: yesMolecular Nutrition &Food Research, EarlyView.
Metabolic syndrome (MetS)‐related conditions are key factors in liver damage. A Mediterranean lifestyle shows promise in managing MetS, though its mechanisms remain unclear. This study tested a lab‐designed food mix mimicking the 1960s Mediterranean Diet (MD) on obese and diabetic mice; it prevented hyperlipidemia and reduced oxidative liver damage ...
Giovanna Mercurio   +13 more
wiley   +1 more source

Further observations on the incidence and nature of atypical creatine kinase activity. [PDF]

open access: bronze, 1979
Sylvan M Sax   +3 more
openalex   +1 more source

Bioavailability of Magnesium and Potassium Salts Used as Potential Substitutes for Sodium Chloride in Human Nutrition — A Review

open access: yesMolecular Nutrition &Food Research, EarlyView.
A high intake of sodium chloride contributes to hypertension. This review evaluates the bioavailability of potassium and magnesium salts as sodium chloride alternatives. Potassium chloride and citrate, as well as magnesium citrate and chloride, show good absorption.
Ronja Merschmann   +3 more
wiley   +1 more source

Denoising Low‐Power CEST Imaging Using a Deep Learning Approach With a Dual‐Power Feature Preparation Strategy

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose: Low‐power (LP) chemical exchange saturation transfer (CEST) Z‐spectra have significantly reduced confounding effects and enhanced peak resolvability, thereby improving the observation and quantification of various CEST effects. However, LP Z‐spectra suffer greatly from reduced contrast‐to‐noise ratio (CNR).
Yashwant Kurmi   +6 more
wiley   +1 more source

Quantification of Tryptophan and NAD+ Proton Magnetization Exchange With Water Using Downfield 1H MRS in the Human Brain at 7 T

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose The purpose of this study was to investigate the effect of magnetization exchange on the measurement of tryptophan and NAD+ T1 relaxation times and to determine the magnetization exchange rates with a two‐spin system model using downfield 1H MRS spectroscopy at 7 T in human brain.
Sophia Swago   +5 more
wiley   +1 more source

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