Results 31 to 40 of about 1,019,575 (429)
Exosomes and their roles in the chemoresistance of pancreatic cancer
Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022 Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan +4 more
wiley +1 more source
Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation. [PDF]
, 2019 The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasomes regulatory particle, consisting of lid
Aufderheide +42 more
core +1 more source
Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore [PDF]
, 1996 In vitro incubation of isolated hexokinase isozyme I or isolated dimer of mitochondrial creatine kinase with the outer mitochondrial membrane pore led to high molecular weight complexes of enzyme oligomers.
Beutner, Gisela +4 more
core +1 more source
Creatine Kinase Gene Mutation in a Patient with Muscle Creatine Kinase Deficiency [PDF]
Clinical Chemistry, 2001 AbstractBackground: We describe a 56-year-old woman admitted to the hospital with a diagnosis of acute myocardial infarction without an increase of serum creatine kinase (CK) activity during her clinical course. She died on the 11th hospital day, and the diagnosis was confirmed by autopsy.
Takumi Jikimoto +8 more
openaire +3 more sources
ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022 Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley +1 more source
Rapid, $B_1$-insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux [PDF]
, 2020 Purpose: Phosphorus saturation-transfer experiments can quantify metabolic fluxes non-invasively. Typically, the forward flux through the creatine-kinase reaction is investigated by observing the decrease in phosphocreatine (PCr) after saturation of $\gamma$-ATP.
arxiv +1 more source
³¹P Saturation Transfer and Phosphocreatine Imaging in the Monkey Brain [PDF]
, 1991 ³¹P magnetic resonance imaging with chemical-shift discrimination by selective excitation has been employed to determine the phosphocreatine (PCr) distribution in the brains of three juvenile macaque monkeys.
Allman, John +4 more
core +1 more source
Catheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1159-1170, December 1, 2022., 2022 Abstract Background Clinical factors favouring coronary angiography (CA) selection and variables associated with in‐hospital mortality among patients presenting with out‐of‐hospital cardiac arrest (OHCA) without ST‐segment elevation (STE) remain unclear.
Wayne C. Zheng +15 more
wiley +1 more source
Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review
Nutrients, 2021 Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and pancreas. Most of the Cr pool is found in tissues with high-energy demands.
D. Bonilla +6 more
semanticscholar +1 more source
Antioxidants, 2022 The aim of this study was to explore the use of coenzyme Q10 and skeletal muscle protein biomarkers in the diagnosis of sarcopenia. Subjects with or without sarcopenia were recruited.
Chi-Hua Yen +3 more
doaj +1 more source