Results 101 to 110 of about 15,296 (267)

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Creatine Transporter Deficiency Presenting as Autism Spectrum Disorder

, 2020
Autism spectrum disorder (ASD) is the most common disability-causing neurodevelopmental disorder in childhood. Although inborn errors of metabolism (IEM) are rare causes of ASD, they are significant for several reasons, including implications in genetic ...
Haliloğlu, G, Yaramış, A, Yıldız, YILMAZ, Göçmen, R, Coşkun, T   +4 more
core   +1 more source

Venous blood lactate concentration as a predictor of intestinal viability in horses with acquired indirect inguinal hernia

Equine Veterinary Journal, EarlyView.
Abstract Background Acquired indirect inguinal hernia represents a life‐threatening emergency. Therapeutic decision‐making largely depends on intestinal viability, for which specific predictive parameters (such as venous lactate) have not been evaluated.
Raquel Rivero‐García, Cristina Andreu‐Vázquez, Beatriz Fuentes‐Romero, Pablo Fernández‐Hernández, María Luisa Rodríguez‐Pozo, Ignacio Aguilar Sebastián, Salvador Termes Soto, Mercedes Martínez Gallardo, Manuel Iglesias‐García   +8 more
wiley   +1 more source

Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models

BMC Neuroscience, 2010
Background In order to confirm the roles of creatine (Cr) in epilepsy, we investigated the anti-convulsive effects of Cr, creatine transporter (CRT) and creatine kinases (CKs) against chemical-induced acute seizure activity and chronic epileptic seizure ...
Kim Ji-Eun, Ryu Hea, Yeo Seong-Il, Kim Dae, Song Hong-Ki, Kwon Oh-Shin, Choi Soo, Kang Tae-Cheon   +7 more
doaj   +1 more source

Ontogeny up-regulates renal Na+/Cl−/creatine transporter in rat

, 2007
Creatine plays a role in energy storage and transport/shuttle of high-energy phosphate in heart, brain, retina, testis and skeletal muscle. These tissues take creatine from the plasma via a 2Na+/1Cl−/1creatine cotransporter (CRT).
García-Delgado, M., García-Miranda, P., Ilundáin, A.A., Peral, M.J., Calonge, M.L.   +4 more
core   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

Dodecyl creatine ester and lipid nanocapsule: a double strategy for the treatment of creatine transporter deficiency.

, 2014
Background: Creatine transporter (CT) deficiency is characterized by mutations in the gene encoding CT, leading to impaired transport of creatine at the cell membrane.
S. Dézard, J. Bejaud, F. Taran, Mabondzo, Aloïse, de Lonlay, Pascale, V. Valayannopoulos, A. Mabondzo, A. Trotier-Faurion, Taran, Fréderic, Trotier-Faurion, Alexandra, C. Passirani-Malleret, P. de Lonlay, Bejaud, Jérôme, J.P. Benoît, Valayannopoulos, Vassili, Dézard, Sophie, Benoit, Jean-Pierre, Passirani-Malleret, Catherine   +17 more
core   +1 more source

Implantable electrochemical sensors for continuous blood monitoring

FlexMat, EarlyView.
Implantable electrochemical sensors enable direct, in situ, and continuous blood monitoring, shifting diagnosis from population‐based averages to dynamic, individualized analysis. This review systematically examines the influence of the unique blood properties on sensor design.
Kuangyi Zou, Yuanzhen Wang, Haidong Wang, Ye Zhang   +3 more
wiley   +1 more source

Intratesticular creatine maintains spermatogenesis by defining tight junctions

Scientific Reports
One in five couples who wish to conceive is infertile, and half of these couples have male infertility. However, the causes of male infertility are still largely unknown.
Sohei Kuribayashi, Shinichiro Fukuhara, Hiroaki Kitakaze, Go Tsujimura, Takahiro Imanaka, Norichika Ueda, Kentaro Takezawa, Masahito Ikawa, Norio Nonomura   +8 more
doaj   +1 more source

Impaired brain glucose metabolism as a biomarker for evaluation of dodecyl creatine ester in creatine transporter deficiency: Insights from patient brain-derived organoids and in vivo [18F]FDG PET imaging in a mouse model

Neurobiology of Disease
Creatine transporter deficiency (CTD) is an inborn error of creatine (Cr) metabolism in which Cr is not properly distributed to the brain due to a mutation in the Cr transporter (CrT) SLC6A8 gene.
Clémence Disdier, Amélie Soyer, Léa Broca-Brisson, Sébastien Goutal, Anne-Cécile Guyot, Nora Ziani, Louise Breuil, Alexandra Winkeler, Gaëlle Hugon, Thomas Joudinaud, Henri Bénech, Jean Armengaud, Matthew R. Skelton, Rania Harati, Rifat A. Hamoudi, Nicolas Tournier, Aloïse Mabondzo   +16 more
doaj   +1 more source