Results 141 to 150 of about 191,979 (223)

Structure-Based Search for Novel Creatine Transporter Inhibitors. [PDF]

ACS Med Chem Lett
Stary D, El-Kasaby A, Boytsov D, Zaręba P, Godyń J, Maszczyk M, Rzepka Z, Wrześniok D, Sotriffer C, Sandtner W, Freissmuth M, Bajda M.   +11 more
europepmc   +1 more source

New Insights Into Pathogenesis, Diagnostics, and Therapeutic Options for Canine Angiostrongylosis

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To provide a comprehensive overview of Angiostrongylus vasorum infection in dogs, with a particular emphasis on recent developments in the understanding of disease pathophysiology and an update on developments in diagnostic and therapeutic options.
Iris Elgueta, Daniel Lewis, Eric R. Morgan, Jenny Helm   +3 more
wiley   +1 more source

Delineation of Facial Dysmorphology in Males With Creatine Transporter Defect. [PDF]

Am J Med Genet A
Perreault J, Porter FD, Nowaczyk MJM.
europepmc   +1 more source

Gastrointestinal microbiota and barrier integrity in individuals who develop exertional heat illness and pair‐matched controls: A prospective observational cohort study

Experimental Physiology, EarlyView.
Abstract It has been hypothesised that the composition of the gastrointestinal (GI) microbiota contributes to exertional heat illness (EHI) aetiology, but relevant empirical data in humans are lacking. Utilising a unique prospective study design, stool samples and resting blood samples were obtained from 550 individuals prior to (within 3 days ...
Alex A. M. Gould, Neil P. Walsh, Michael J. Tipton, Michael J. Zurawlew, Samuel C. Robson, Janis K. Shute, Joy E. M. Watts, Hayley C. Tyson, Megan R. Robinson, Andrew J. Roberts, Alex J. Rawcliffe, Ross Hemingway, Jo Corbett   +12 more
wiley   +1 more source

Fuelled by creatine: exploring two copies of the creatine transporter SLC6A8 gene in rainbow trout. [PDF]

Fish Physiol Biochem
Borchel A, Müller-Eigner A, Görs S, Rebl H, Rebl A, Metges CC, Goldammer T, Verleih M.   +7 more
europepmc   +1 more source

S14G‐humanin attenuates renal ischaemia–reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats

Experimental Physiology, EarlyView.
Abstract Renal ischaemia–reperfusion (I/R) injury leads to acute tubular necrosis and renal failure, triggering pathological mechanisms including inflammation, reactive oxygen species generation, apoptosis and mitochondrial dysfunction. The mitochondrial peptide humanin (HN), known to possess anti‐apoptotic and anti‐inflammatory properties, has been ...
Leyla Abueid, Ahmet Faruk Torun, Ezgi Golal, Nuray Acar, Filiz Basrali   +4 more
wiley   +1 more source

Optimizing Gene Therapies for Creatine Transporter Deficiency: Correcting by Connecting. [PDF]

Epilepsy Curr
Lillis KP.
europepmc   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Connectomic and behavioural alterations in creatine transporter deficiency are partially normalized by gene therapy. [PDF]

Brain
Montani C, Iovino L, Di Vetta F, Pasquin Mariani JR, De Guzman AE, Gini S, Galbusera A, D'Epifanio B, Ghirardini E, Cornuti S, Dadà L, Putignano E, Alessandrì MG, Vasirani G, Bertozzi SM, Armirotti A, Baroncelli L, Gozzi A.   +17 more
europepmc   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source