Results 61 to 70 of about 191,979 (223)

Creatine transporter and mitochondrial creatine kinase protein content in myopathies.

, 2001
International audienceTotal creatine or phosphocreatine, or both, are reduced in the skeletal muscle of patients with inflammatory myopathy, mitochondrial myopathy, and muscular dystrophy/congenital myopathy.
Schlattner, Uwe, Tarnopolsky, M. A., Walzel, B., Wallimann, Theo, Parshad, A.   +4 more
core   +1 more source

Screening for creatine transporter deficiency in autism spectrum disorder: a pilot study

Türk Biyokimya Dergisi
Investigation of inherited metabolic disorders in autism spectrum disorder (ASD) is a matter of debate. X-linked creatine transporter deficiency is among the metabolic disorders which may present predominantly with features of ASD and intellectual ...
Arslan Mutluay, Yildiz Yılmaz, Olgaç Asburçe, Hekim Özlem, Yücel Çiğdem, Sertoğlu Erdim   +5 more
doaj   +1 more source

The cataract and Glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter [PDF]

, 2013
Creatine transport has been assigned to creatine transporter 1 (CRT1), encoded by mental retardation associated SLC6A8. Here, we identified a second creatine transporter (CRT2) known as monocarboxylate transporter 12 (MCT12), encoded by the cataract and ...
Munier, Francis L, Zuercher, Jurian, Verrey, François, Munier, F.L., Berger, Wolfgang, Camargo, S.M., Kloeckener-Gruissem, Barbara, Neidhardt, J., Zuercher, J., Verrey, F., Camargo, Simone M R, Abplanalp, J., Philp, N.J., Laczko, Endre, Abplanalp, Jeannette, Schorderet, D.F., Neidhardt, John, Laczko, E., Philp, Nancy J, Braun, Philipp, Braun, P., Philp, Nancy J., Schorderet, Daniel F., Munier, Francis L., Kloeckener-Gruissem, B., Schorderet, Daniel F, Camargo, Simone M. R., Berger, W., Abplanalp, Jeanette   +28 more
core   +2 more sources

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source

Creatine in Sustainable Fish Aquaculture

, 2023
Creatine is a popular ergogenic sport supplement used to improve exercise performance and muscle growth in athletes. Further, studies suggest protective effects of creatine in neurodegenerative diseases, type 2 diabetes, osteoarthritis, fibromyalgia ...
Powell, Madison S. S., Ramirez, Carolina, Pereira, Wellison A. A., Dantagnan, Patricio, Romero, Jaime, Figueroa Villalobos, Elias, Villasante, Alejandro, Gatlin, Delbert M. M.   +7 more
core  

Low‐Field MRI as a Multiparametric Tool for Large Engineered Tissue Characterization

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Advances in 3D bioprinting have enabled the fabrication of large and complex engineered tissues, but their increasing size demands non‐invasive tools for monitoring structure, maturation, and perfusion. Magnetic Resonance Imaging (MRI) offers unique multiparametric capabilities, yet high‐field systems remain costly and inaccessible for most ...
Yilbert Gimenez, Valernst Martial Gilmus, Elliott Cowles, Lucie Essayan, Vincent Semet, Michel Cabrera, Christophe A. Marquette, Simon A. Lambert, Emma Petiot   +8 more
wiley   +1 more source

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts

Pharmacology Research & Perspectives, 2019
Creatine transporter deficiency (CTD) is a metabolic disorder resulting in cognitive, motor, and behavioral deficits. Cyclocreatine (cCr), a creatine analog, has been explored as a therapeutic strategy for the treatment of CTD.
Kirill Gorshkov, Amy Q. Wang, Wei Sun, Ethan Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh‐Ha T. Do, Elizabeth A. Ottinger, Xin Xu, Wei Zheng   +13 more
doaj   +1 more source

X-Linked Creatine-Transporter Gene (SLC6A8) Defect: A New Creatine-Deficiency Syndrome [PDF]

, 2001
We report the first X-linked creatine-deficiency syndrome caused by a defective creatine transporter. The male index patient presented with developmental delay and hypotonia.
van Dooren, Silvy J.M., Salomons, Gajja S., Degrauw, Ton J., Cecil, Kim M., Ball, William S., Jakobs, Cornelis, Verhoeven, Nanda M.   +6 more
core   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source