Results 151 to 160 of about 612,233 (251)

Severe epilepsy in X-linked creatine transporter defect (CRTR-D)

, 2007
Disorders of creatine synthesis or its transporter resulting in neurological impairment with mental retardation and epilepsy have only been recognized in recent years.
JAKOBS C, ZARA F, GAGGERO R., BAGLIETTO, MARIA GIUSEPPINA, CARUSO U, SCHIAFFINO MC, VENESELLI, EDVIGE MARIA, MANCARDI MM, ROSSI A, BATTAGLIA FM, SALOMONS GS   +10 more
core   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Chemical optimization of creatine derivatives for the treatment of creatine transporter deficiency

, 2013
Creatine transporter deficiency is a rare brain disease associated with the loss of function of the SLC6A8 (creatine transporter) leading to an absence of creatine at the cerebral level and to a dramatic neurodevelopmental retardation in the children.
openaire   +2 more sources

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Creatine transporter expression in skeletal muscle

, 2002
Creatine is an important molecule involved in providing energy to the body. Its major stores are in skeletal muscle. The creatine transporter protein (CreaT) mRNA is believed to be responsible for the uptake of the majority of creatine in skeletal muscle.
Robyn. Murphy (13782355)
core  

β‐hydroxy‐β‐methylbutyrate improves fast‐twitch muscle function, histopathology and mitochondrial respiration in the D2.mdx dystrophic mouse

The Journal of Physiology, EarlyView.
Abstract figure legend β‐Hydroxy‐β‐methylbutyrate (HMB) enhances fast‐twitch muscle and mitochondrial function in D2.mdx mice. Male DBA/2J (wild‐type) and D2.mdx mice aged 3 or 6 months received daily β‐hydroxy‐β‐methylbutyrate (HMB; 1 mg g−1 day−1) via drinking water for 8 weeks. Fast‐twitch extensor digitorum longus (EDL) and slow‐twitch soleus (SOL)
Nicholas Giourmas, Hannah Lalunio, Memphis Calzoni, Ryan Bagaric, Craig A. Goodman, Alan Hayes   +5 more
wiley   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Impact of Sprint Duration With Fixed Recovery on Acute Physiological and Performance Responses to Repeated Cycle Sprints in Hypoxia in Male and Female Sprinters

European Journal of Sport Science, Volume 26, Issue 10, October 2026.
ABSTRACT Repeated short sprints (≤ 10 s) in hypoxia are often used to enhance performance, but acute responses to longer sprints (> 10 s) performed in a repeated‐sprint format with short recovery periods (∼30 s) remain unclear. We examined performance and physiological strain during repeated short (10‐s) and long (15‐s) sprints with identical recovery (
Naoya Takei, Ryuji Muraki, Olivier Girard, Hideo Hatta, Yumiko Takahashi   +4 more
wiley   +1 more source

Creatine transporter deficiency, an underdiagnosed cause of male intellectual disability. [PDF]

BMJ Case Rep, 2020
Jangid N, Surana P, Salmonos G, Jain V.
europepmc   +1 more source