Results 51 to 60 of about 612,233 (251)

Reduction in cardiolipin reduces expression of creatine transporter-1 and creatine transport in growing hCMEC/D3 human brain microvessel endothelial cells

Frontiers in Drug Delivery, 2023
The phospholipid cardiolipin (CL) regulates mitochondrial energy production. Endothelial cells of the blood-brain barrier (BBB) play a vital role in uptake of metabolites into the brain and are enriched in mitochondria.
Donald W. Miller, Grant M. Hatch, Grant M. Hatch   +2 more
doaj   +1 more source

Creatine protects against excitoxicity in an in vitro model of neurodegeneration. [PDF]

, 2012
Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury. As a common molecular background, oxidative stress and disturbed cellular energy homeostasis are key aspects in these conditions. Moreover, in a recent
Geiger Johanna, Bender Andreas, Klopstock Thomas, Rujescu Dan, Genius, Just, Möller, Hans-Jürgen, Geiger, Johanna, Just Genius, Thomas Klopstock, Johanna Geiger, Klopstock, Thomas, Genius Just, Dan Rujescu, Andreas Bender, Möller Hans-Jürgen, Bender, Andreas, Hans-Jürgen Möller, Rujescu, Dan   +17 more
core   +1 more source

CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport

OncoImmunology, 2023
Pancreatic cancer (PC) is featured with low survival rate and poor outcomes. Herein, we found that the expression of caspase-recruitment domain-containing protein 9 (CARD9), predominantly expressed in innate immune cells, was positively related to the ...
Cheng Tian, Huimin Yuan, Yi Lu, Henghui He, Qing Li, Senlin Li, Jian Yang, Mengheng Wang, Ruochen Xu, Qian Liu, Ming Xiang   +10 more
doaj   +1 more source

Creatine salts provide neuroprotection even after partial impairment of the creatine transporter [PDF]

, 2017
Creatine, a compound that is critical for energy metabolism of nervous cells, crosses the blood-brain barrier (BBB) and the neuronal plasma membrane with difficulty, and only using its specific transporter.
Salis, A., Garbati, P., Damonte, G., GARBATI, PATRIZIA, BALESTRINO, MAURIZIO, Adriano, E., Millo, E., ADRIANO, ENRICO GIOVANNI, SALIS, ANNALISA, DAMONTE, GIANLUCA, MILLO, ENRICO, Balestrino, M.   +11 more
core   +1 more source

A rare thyroid disorder mimicking mitochondrial disease [PDF]

Biomedicinska istraživanja, 2021
Introduction. Patients affected with Allan-Herndon-Dudley syndrome (AHDS) have a deficiency of monocarboxylate transporter 8 (MCT8), a protein primarily responsible for the transport of triiodothyronine (T3) into the brain.
Adrijan Sarajlija, Sladjana Todorović, Biljana Alimpić, Maja Čehić   +3 more
doaj   +1 more source

Creatine Transporter Deficiency in Two Brothers with Autism Spectrum Disorder [PDF]

, 2018
Background Creatine transporter deficiency (CTD) is a treatable, X-linked, inborn error of metabolism. Case characteristics Two brothers with autism spectrum disorder were diagnosed with CTD at ...
Halil Ibrahim Aydin, Aydin, Halil Ibrahim   +1 more
core   +1 more source

Treatment experience in two adults with creatinfe transporter deficiency

Molecular Genetics and Metabolism Reports, 2021
Background: Creatine transporter deficiency (CTD) is an X-linked form of intellectual disability (ID) caused by SCL6A8 mutations. Limited information exists on the adult course of CTD, and there are no treatment studies in adults.
Jack Schjelderup, Sigrun Hope, Christian Vatshelle, Clara D.M. van Karnebeek   +3 more
doaj   +1 more source

Upregulation of the Creatine Transporter Slc6A8 by Klotho

Kidney & Blood Pressure Research, 2014
Background/Aims: The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation. The extracellular domain of Klotho protein could function as an enzyme with e.g. β-glucuronidase activity, be cleaved off and be released into blood and
Ahmad Almilaji, Mentor Sopjani, Bernat Elvira, José Borras, Miribane Dërmaku-Sopjani, Carlos Munoz, Jamshed Warsi, Undine E. Lang, Florian Lang   +8 more
doaj   +1 more source

Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. [PDF]

PLoS ONE, 2011
Mutations in the creatine (Cr) transporter (CrT; Slc6a8) gene lead to absence of brain Cr and intellectual disabilities, loss of speech, and behavioral abnormalities.
Matthew R Skelton, Tori L Schaefer, Devon L Graham, Ton J Degrauw, Joseph F Clark, Michael T Williams, Charles V Vorhees   +6 more
doaj   +1 more source

The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds.

, 2006
Hereditary creatine transporter deficiency causes brain damage, despite the brain having the enzymes to synthesize creatine. Such damage occurring despite an endogenous synthesis is not easily explained.
Lunardi G, Gandolfo C, Cupello A, Balestrino M, Florio T, Perasso L, Pohvozcheva AV, Parodi A, Burov SV, Adriano E, Scarrone S   +10 more
core   +2 more sources