Results 61 to 70 of about 612,233 (251)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart. [PDF]

PLoS ONE, 2014
Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism. The functional significance for the heart has yet to be established, but antioxidant activity could contribute to the ...
Dunja Aksentijević, Sevasti Zervou, Kiterie M E Faller, Debra J McAndrew, Jurgen E Schneider, Stefan Neubauer, Craig A Lygate   +6 more
doaj   +1 more source

Prominent U-waves Without QT Prolongation in X-linked Creatine Transporter Deficiency Caused by SLC6A8 Variants.

Heart Rhythm
BACKGROUND Creatine transporter deficiency (CTD) is a rare X-linked disease caused by SLC6A8 variants, which impair ATP-dependent energy metabolism in neurons and myocytes.
Antoine Delinière, Chloé Mulatier, David Cheillan, Farha Gheurbi, Marion Buchy, Nathalie Dufay, Anne Moulin-Zinsch, Claire Bertail-Galoin, M. Sabour, Mariama Aarab, Thomas Perouse de Montclos, Diane Ouvrier-Buffet, A. Boisson, B. Stos, Mohamed Rharbaoui, G. Remerand, C. Barnerias, A. Brassier, Alice Goldenberg, Agathe Roubertie, Laurence Lion-François, S. Marignier, P. de Lonlay, F. Mochel, V. Navarro, James Lespinasse, Didier Lacombe, R. Touraine, S. Rheims, V. D. Portes, Philippe Chevalier, A. Curie   +31 more
semanticscholar   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source

An international cross-sectional survey to characterize the humanistic burden of creatine transporter deficiency

Future Rare Diseases, 2022
Aim: The purpose of this research was to collect caregiver-reported data on the burden of creatine transporter deficiency (CTD). Materials & methods: Following institutional review board approval, caregivers of individuals with CTD were recruited through
A. Evins, T. Cimms, S. Blair, J. Whyte, M. Paulich, E. Hribal, C. Evans, M. Brandabur   +7 more
semanticscholar   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Effects of SLC6A8 mutation-induced creatine deficiency on cellular function in fibroblasts

Scientific Reports
Creatine transporter deficiency (CTD) caused by mutations in SLC6A8 encoding the creatine transporter (CRT), leads to cerebral creatine deficiency syndromes; however, the cellular impact of CRT loss remains unclear.
Shingo Ito, Tatsuki Uemura, Ayaka Miyano, Hiroko Shimbo, Takeshi Masuda, Tomohide Goto, Hitoshi Osaka, Takahito Wada, Sumio Ohtsuki   +8 more
doaj   +1 more source

Modern approaches to the diagnosis and treatment of X-linked creatine transporter deficiency: literature review and own observation

INTERNATIONAL NEUROLOGICAL JOURNAL
Background. X-linked creatine transporter deficiency (CTD) is a rare genetic metabolic disorder causing significant neurological impairments. It results from mutations in the SLC6A8 gene, which disrupt creatine transport into the brain.
Y. Antypkin, L. Kyrylova, O. Miroshnikov, O. O. Dolenko, V. M. Badiuk   +4 more
semanticscholar   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source