Results 61 to 70 of about 643,233 (285)

Bus stop design strategy based on visual comfort level in Bandung City

open access: yesARTEKS : Jurnal Teknik Arsitektur
High sunlight and poor air quality in the city of Bandung affect the level of visual comfort. In designing bus stops, space is needed that has visual comfort so that the facilities are maintained and can function well.
Nada Elfira Dwi Kania   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

FACEBOOK FOR INTERCULTURAL COMMUNICATION: THE FOREIGN STUDENTS’ EXPERIENCE

open access: yesJournal of International Studies, 2020
Computer-mediated communication has been an integral part of how people communicate in today’s modern society. The study of the impact of social media on intercultural competency is still in its infancy and has intrigued many scholars and researchers.
Raja Rodziah Raja Zainal Hassan   +3 more
doaj  

NSW Creative Industries Economic Profile [PDF]

open access: yes, 2013
Economic profile of the NSW and Australian Creative Industries ...
Dixon, T
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

The relationship between communication and education through the creative personality of the teacher

open access: yesCreativity Studies, 2019
The article focuses on the relationships of communication and educational processes, creativity aspects in the context of higher education. A creative personality of the teacher determines how smooth and efficient these relationships are.
Vida Navickienė   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Integration of Kansei Engineering and Nudge Based Design Thinking for Patient Comfort in Healthcare Services

open access: yesJurnal Teknik Industri
Healthcare often struggles to obtain patient comfort and autonomy, leading to confusion, frustration, and dependency on healthcare staff. In addressing this concern, this study is conducted to propose an integrative framework of Kansei Engineering (KE ...
Markus Hartono   +5 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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