Results 71 to 80 of about 225,562 (293)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Data for Macroalgae exhibit diverse responses to human disturbances on coral reefs
<b>External Organisations</b><br/>University of British Columbia; ARC Centre of Excellence for Coral Reef Studies; University of Victoria BC; Nova Southeastern University; University of Leeds; Lancaster University; Université PSL; One ...
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
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<b>External Organisations</b><br/>Australian Institute of Marine Science<b>Associated Persons</b><br/>Anton Kuret (Creator); Cordelia Moore (Creator); Samantha Maticka (Creator); David Spencer (Creator); Joey Voermans (
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GENERAL THEORY OF THE UNIVERSE
Модернизация, инновация, развитие, 2016 The World Creation and World genetic, energy and information Unity Theory is created. Created on its basis is a theory of the Creator’s Self-creation and of the Creation by Him of the World Basic Genome as basis for World evolution and his General Laws ...
B. A. Astafyev
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Stylistyka, 2021 WorkIn this paper we have posited the basie thesis that a created work of art depends exclusive- ly on its creator, namely on his worldview, his experience of the world. Two authors are discussed here, the poets V. Petković Dis and A.
МИЛОСАВ МИЛОСАВ Ж. ЧАРКИЪ ЧАРКИЪ
doaj
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
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Cog Is to Us as We Are to God: A Response to Anne Foerst
Zygon, 1998 Foerst says that a robot must have human features if it is to learn to relate to human beings. She argues that the image of God (imago dei) represents no more than a promise of God to relate to us.
doaj +2 more sources