Results 11 to 20 of about 120,334 (323)

cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia

Frontiers in Molecular Neuroscience, 2018
Dopamine is a brain neurotransmitter involved in the pathology of schizophrenia. The dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is hyperactive.
Haitao Wang, Jiangping Xu, Philip Lazarovici, Remi Quirion, Wenhua Zheng   +4 more
doaj   +3 more sources

CREB inhibits AP-2alpha expression to regulate the malignant phenotype of melanoma. [PDF]

PLoS ONE, 2010
The loss of AP-2alpha and increased activity of cAMP-responsive element binding (CREB) protein are two hallmarks of malignant progression of cutaneous melanoma.
Vladislava O Melnikova, Andrey S Dobroff, Maya Zigler, Gabriel J Villares, Russell R Braeuer, Hua Wang, Li Huang, Menashe Bar-Eli   +7 more
doaj   +1 more source

HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein

Frontiers in Aging Neuroscience, 2022
HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming.
Jenny Shrestha, Jenny Shrestha, Maryline Santerre, Maryline Santerre, Charles N. S. Allen, Charles N. S. Allen, Sterling P. Arjona, Sterling P. Arjona, Carmen Merali, Ruma Mukerjee, Ruma Mukerjee, Kumaraswamy Naidu Chitrala, Jin Park, Asen Bagashev, Viet Bui, Viet Bui, Eliseo A. Eugenin, Salim Merali, Marcus Kaul, Marcus Kaul, Marcus Kaul, Jeannie Chin, Bassel E. Sawaya, Bassel E. Sawaya, Bassel E. Sawaya, Bassel E. Sawaya, Bassel E. Sawaya   +26 more
doaj   +1 more source

Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes. [PDF]

, 2020
Zika virus (ZIKV) infection in the human central nervous system (CNS) causes Guillain-Barre syndrome, cerebellum deformity, and other diseases. Astrocytes are immune response cells in the CNS and an important component of the blood-brain barrier ...
Hu, Q, Ke, X, Li, P, Liu, Y, Mao, P, Sun, J, Tan, Z, Tang, Y, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +12 more
core   +1 more source

NF-κB and CREB are required for angiotensin II type 1 receptor upregulation in neurons. [PDF]

PLoS ONE, 2013
Nuclear factor kappa B (NF-κB) and the Ets like gene-1 (Elk-1) are two transcription factors that have been previously established to contribute to the Angiotensin II mediated upregulation of Angiotensin II type 1 receptor (AT1R) in neurons.
Karla K V Haack, Amit K Mitra, Irving H Zucker   +2 more
doaj   +1 more source

The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila

Cell Death and Disease, 2022
cAMP Responsible Element Binding Protein (CREB) is an evolutionarily conserved transcriptional factor that regulates cell growth, synaptic plasticity and so on.
Youjie Yin, Peng Ma, Saifei Wang, Yao Zhang, Ruolei Han, Chunyu Huo, Meixian Wu, Hansong Deng   +7 more
doaj   +1 more source

Berberine Suppresses Adipocyte Differentiation via Decreasing CREB Transcriptional Activity. [PDF]

PLoS ONE, 2015
Berberine, one of the major constituents of Chinese herb Rhizoma coptidis, has been demonstrated to lower blood glucose, blood lipid, and body weight in patients with type 2 diabetes mellitus.
Juan Zhang, Hongju Tang, Ruyuan Deng, Ning Wang, Yuqing Zhang, Yao Wang, Yun Liu, Fengying Li, Xiao Wang, Libin Zhou   +9 more
doaj   +1 more source

CREB-binding protein sequestration by expanded polyglutamine [PDF]

Human Molecular Genetics, 2000
Spinal and bulbar muscular atrophy (SBMA) is one of eight inherited neurodegenerative diseases known to be caused by CAG repeat expansion. The expansion results in an expanded polyglutamine tract, which likely confers a novel, toxic function to the affected protein.
A, McCampbell, J P, Taylor, A A, Taye, J, Robitschek, M, Li, J, Walcott, D, Merry, Y, Chai, H, Paulson, G, Sobue, K H, Fischbeck   +10 more
openaire   +2 more sources

The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells

Frontiers in Oncology, 2020
Acute myeloid leukemia (AML) is a progressive hematopoietic-derived cancer arising from stepwise genetic mutations of the myeloid lineage. cAMP response element-binding protein (CREB) is a nuclear transcription factor, which plays a key role in the ...
Michela Illiano, Mariarosaria Conte, Alessia Salzillo, Angela Ragone, Annamaria Spina, Angela Nebbioso, Lucia Altucci, Luigi Sapio, Silvio Naviglio   +8 more
doaj   +1 more source

A functional analysis of the CREB signaling pathway using HaloCHIP-chip and high throughput reporter assays

BMC Genomics, 2009
Background Regulation of gene expression is essential for normal development and cellular growth. Transcriptional events are tightly controlled both spatially and temporally by specific DNA-protein interactions.
Aldred Shelley F, Murphy Nancy, Mendez Jacqui, Trinklein Nathan D, Hartzell Danette D, Wood Keith, Urh Marjeta   +6 more
doaj   +1 more source