Results 121 to 130 of about 73,335 (261)

Histamine H₁ Receptor-Mediated CREB Phosphorylation via G_q Protein Signaling and Arrestin Modulation. [PDF]

Pharmaceuticals (Basel)
Ogami R, Michinaga S, Iiboshi Y, Ogawa Y, Hishinuma S.   +4 more
europepmc   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Med14 phosphorylation shapes genomic response to GLP-1 agonists. [PDF]

Proc Natl Acad Sci U S A
Van de Velde S, Yu J, Garrett Evensen K, Pakhlevanyan E, Williams AE, Shaw RJ, Montminy M.   +6 more
europepmc   +1 more source

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Excess FGFR3 signaling in achondroplasia disrupts turnover of resting zone chondrocytes via CREB signaling. [PDF]

Nat Commun
Horike N, Oura S, Koyamatsu S, Tanaka N, Iimori Y, Fujita K, Nemoto T, Ikawa M, Tsumaki N.   +8 more
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront. [PDF]

Front Pharmacol
Zhang J, Deng X, Lv J, Lu J, Wang L, Wang W, Lei H, Wang Y, Tian J.   +8 more
europepmc   +1 more source

CBP/β‐Catenin Signaling in Hepatocytes Plays Pivotal Roles in MMP‐7‐Mediated Liver Fibrosis in a Metabolic Dysfunction‐Associated Steatohepatitis Mouse Model

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CDAHFD‐induced hepatic steatosis stimulates CBP/β‐catenin signaling in hepatocytes, leading to increased production of the downstream effector MMP‐7. Hepatocyte‐derived MMP‐7 contributes to fibrogenic responses and is associated with the progression of liver fibrosis.
Jun Imamura, Masamichi Kimura, Yumi Otoyama, Koji Nishikawa, Michinori Kohara, Kiminori Kimura   +5 more
wiley   +1 more source

KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress. [PDF]

J Lipid Res
Liang M, Zhang M, Hou Y, Yuan F, Zhang H, Zhao M, Xu L, Liu Q, Su Y, Chu X, Li W, Wang J, Xie J, Wang C, Cui Q, Zhang J.   +15 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, Volume 7, Issue 1, Page 21-31, March 2026.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source