Results 171 to 180 of about 73,335 (261)

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini, Soheila Karimi‐Abdolrezaee   +1 more
wiley   +1 more source

In Vitro Evaluation of the Inhibitory Effects of Linarin on Histamine‐Induced Expression of Proinflammatory Cytokines, Mucin 5AC, and Aquaporin 5 in Human Nasal and Bronchial Epithelial Cells

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 3, March 2026.
ABSTRACT Allergic rhinitis and asthma are two prevalent chronic allergic conditions in children. Linarin, a glycosylated flavonoid derived from various plants, exhibits a wide range of biological activities. This study aimed to investigate the therapeutic potential of linarin against allergic rhinitis and asthma.
Xin‐Jing Mi, Jie Wang, Jian‐Qiang Qi
wiley   +1 more source

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

Renalase stimulates aldosterone production via PMCA4b/cAMP in NCI-H295R cells. [PDF]

J Enzyme Inhib Med Chem
Fu R, Huang M, Liu T, Chen Y, Li X, Jiang W.   +5 more
europepmc   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

Neuroprotective effects of Cratoxylum formosum (L.) leaf extract on β-amyloid-induced injury in human neuroblastoma SH-SY5Y cells. [PDF]

Sci Rep
Palachai N, Buranrat B, Pariwatthanakun C, Noisa P, Mairuae N.   +4 more
europepmc   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

Effect of Ang II Receptor Inhibition on GSK-3β/CREB/BDNF Signalling in REM Sleep Deprivation-Induced Memory Impairment. [PDF]

Neurochem Res
Elma N, Sayan Özaçmak H, Turan İ.
europepmc   +1 more source

The DYRK Family: A Key Regulator of Metabolic Homeostasis and Its Therapeutic Potential in Kidney Diseases

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The DYRK family, a pivotal metabolic homeostasis regulator, mediates crosstalk between metabolic disorders and CKD via subtype‐specific mechanisms: DYRK1A drives diabetic (CKD risk), DYRK1B exacerbates metabolic renal injury, DYRK2 contributes to renal osteodystrophy, while DYRK3/4 remain unelucidated.
Yixuan Zhu, Pengfei Qiao, Yukun Gan, Xiushuo Fu, Xiayue Huang, Sirui Sun, Yafei Gou, Wenjie Xia, Feng Ma, Limin Liu   +9 more
wiley   +1 more source

UHRF1 deficiency exacerbates intestinal inflammation by epigenetic modulation of NPY1R gene methylation. [PDF]

JCI Insight
Han Y, Sun L, Liu Y, Zhang X, Liu H, Zhang H, Ren X, Wang F, Fan H, Chen J, Liu D, Fan D, Lu Y, Bai X, Fang Y, Wu K, Zhao X.   +16 more
europepmc   +1 more source