Results 191 to 200 of about 146,934 (341)

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

Trazodone modulates behavioral alterations in scopolamine-induced cognitive deficit by targeting brain-derived neurotropic factor and cAMP response element-binding protein signaling. [PDF]

Front Cell Neurosci
Dhaka P, Pinky, Neha, Khan MA, Rabbani SA, El-Tanani M, Parvez S.   +6 more
europepmc   +1 more source

Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells

, 2008
Manrong Jiang, Kejin Zhu, José Grenet, Jill M. Lahti   +3 more
openalex   +2 more sources

CIDEC Restricts Liver Regeneration by Disturbing Lipid Droplet Triglyceride Turnover

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study identifies CIDEC, an lipid droplet (LD)‐fusion associated protein upregulated by CREBH during early regeneration, as a negative regulator of liver regeneration through its unexpected role in sequestering triglyceride (TG) within LDs. CIDEC depletion reduces LD size, mobilizes LD‐stored TG, enhances TG catabolism and free fatty acid (FFA ...
Feng Ouyang, Yining Li, Zixuan Zhang, Fangfang Sun, Yihong Shi, Qian Gui, Da Luo, Changyong Hu, Hang Su, Kaiqi Shen, Lu Gao, Hui Yang, Feng‐Jung Chen, Rong Li, Tong‐Jin Zhao, Peng Li, Tian‐Shu Yang   +16 more
wiley   +1 more source

ucOCN Promotes Testosterone Synthesis via the PKA-MAPK/ERK-CREB Signaling Pathway in Porcine Leydig Cells. [PDF]

Cells
Yang G, Liu H, Yin Z, Zhao L, Chen Y, Li Y, Cheng L, Ma J, Yu J, Zhang Y, Li X, Li R.   +11 more
europepmc   +1 more source

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

CREB-Phosphorylierung und CRE-Aktivierung in murinen Hypothalamuszellen

, 2017
Evi Glas
openalex   +2 more sources

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Renalase stimulates aldosterone production via PMCA4b/cAMP in NCI-H295R cells. [PDF]

J Enzyme Inhib Med Chem
Fu R, Huang M, Liu T, Chen Y, Li X, Jiang W.   +5 more
europepmc   +1 more source

TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease

Advanced Science, Volume 13, Issue 3, 14 January 2026.
TNEA improves cognition in 5xFAD mice by modulating parvalbumin‐positive interneurons in hippocampal CA1. TNEA enhances gamma oscillations during rest and theta power during novel object recognition, restoring excitation/inhibition balance. These findings support TNEA as a minimally invasive therapy for Alzheimer's disease.
Zhongzhao Guo, Hong Ni, Yu Lu, Zhengyu Cui, Yixing Wang, Zilu Zhu, Xinyu Wei, Chenyi Xia, Ming Xu, Lixia Du, Yufang Yang, Shi Shu, Ke Wang, Zhifei Wang, Chunlei Shan, Deheng Wang   +15 more
wiley   +1 more source