Results 191 to 200 of about 73,335 (261)

Nerandomilast attenuates idiopathic inflammatory myopathy-associated interstitial lung disease via inhibiting proliferation and differentiation of B cells. [PDF]

Front Immunol
Liu Y, Hu Y, Se-Rigeleng, Yang Z, Liu X, Yu J, Li H, Gu S, Yang W, Yang C, Zhou H, He Y, Kong C, Gu X, Li X.   +14 more
europepmc   +1 more source

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Epilepsia, Volume 67, Issue 3, Page 1449-1468, March 2026.
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, José M. Serratosa, Lucilla Parnetti, Miriam Sciaccaluga   +17 more
wiley   +1 more source

Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation. [PDF]

Int J Mol Sci
Hong S, Lim H, Kim DH.
europepmc   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Cang-Ai Volatile Oil Mitigates Lipopolysaccharide-Induced Depressive-Like Behaviour in Mice by Modulating the Microglial BDNF/CREB Signaling Pathway. [PDF]

Mol Neurobiol
Zhao L, Yin R, Zhang K, Huang J, Zheng R, Zhu Y, Li G, Lei N, Xiong L, Xie Y.   +9 more
europepmc   +1 more source

Neuroprotective Effects of Strength Training on Behavioral Deficit, Oxidative Damage, Astrogliosis, and Neuronal Death in a Bipolar Disorder Model

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Schematic representation of the neuroprotective effects of strength training in an ouabain‐induced model of bipolar disorder. The intracerebroventricular injection of ouabain induces behavioral alterations (manic‐ and depressive‐like behaviors and cognitive deficits), increases oxidative stress (↑reactive species, ↓antioxidant defenses), promotes ...
Luan Machado Maidana, Jozyê Milena da Silva Guerra, Adson Souza‐Pereira, Mustafa Munir Mustafa Dahleh, Douglas Buchmann Godinho, Marina Prigol, Luiz Fernando Freire Royes, Leonardo Magno Rambo   +7 more
wiley   +1 more source

CaMKII as a Multimodal Signalling Hub in Neural Connectivity and Vulnerability. [PDF]

Mol Neurobiol
Olliff S, Sundaramoorthy V.
europepmc   +1 more source

Engram Synapses and Synapse Dynamics in Memory Processing

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Learning‐induced neuronal activity dynamically rewires synapses, altering their formation and elimination rates in task‐related regions. In vivo two‐photon imaging has revealed that activity‐driven presynaptic, postsynaptic, and astrocytic mechanisms regulate synaptogenesis and axonal bouton engulfment.
Yongmin Sung, Chaery Lee, Hyunsu Jung, Bong‐Kiun Kaang   +3 more
wiley   +1 more source

Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies. [PDF]

Signal Transduct Target Ther
Rozengurt E, Eibl G.
europepmc   +1 more source

CREB Fuels Tumorigenesis in Alcoholic Pancreatitis. [PDF]

Cell Mol Gastroenterol Hepatol
Sardarni UK, Bailey-Lundberg JM.
europepmc   +1 more source