Results 81 to 90 of about 23,863,179 (302)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
A simplified log creep model for describing triaxial creep of mélange rocks. [PDF]
Heliyon, 2023 Oh H +6 more
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Research on Creep Constitutive Model for High Temperature Reactor Based on Neural Network
Yuanzineng kexue jishuThis research aims to develop a novel creep constitutive model, leveraging neural networks to precisely predict long-term creep behavior from short-term data.
ZHANG Fan, DAI Shoutong
doaj +1 more source
工程科学学报, 2017 Contact strain measurement is a tool for studying the high temperature mechanical behavior of components and materials. The measurement precision is the key point of the high temperature strain measurement field, where creep is the main factor that ...
WANG Wen-rui +3 more
doaj +1 more source
A practical creep model for concrete elements under eccentric compression
Materials Structure, 2019 Many prestressed concrete bridges are reported to suffer from excessive vertical deflections and cracking during their service life. Creep softens the structure significantly, and therefore an accurate prediction of creep is necessary to determine long ...
Haidong Huang +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Scientific ReportsMuddy siltstone combines the characteristics of both sandstone and mudstone, and is prone to instability over time. To study the long-term stability of tunnel engineering in this stratum, this article taking the cross-river metro tunnel section as the ...
Huijuan Deng +5 more
doaj +1 more source
Journal of Rock Mechanics and Geotechnical EngineeringUnderstanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue. In this context, we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.
Yachen Xie +3 more
doaj +1 more source