Results 101 to 110 of about 29,880 (311)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Material plastic properties characterization using a generic algorithm and finite element method modelling of the plane-strain small punch test

, 2010
In this paper, a novel plane strain small punch test (SPT) method is proposed for material plastic properties characterization. The plane strain SPT is different from the standard SPT in the two ways: (a) a long thin rectangular specimen (with dimensions
Pan, Wenke, Ramlan, Mohd., Dun, Craig, Pan, W., Boyle, James, Hakoda, Kenji, Hakoda, K., Ismail, Mohd., Boyle, Jim, Dun, C.   +9 more
core  

Redesigning the Austroads creep procedure for the evaluation of permanent deformation of asphalt pavements in Australia [PDF]

, 2017
The broad spectrum of dynamic creep tests developed over the last decade around the world is one of the more significant innovations in the prediction and analysis of the behaviour of asphalt pavements. Although current laboratory creep test methods have
Ahmadinia, Esmaeil
core  

In-situ Creep Testing Capability Development for Advanced Test Reactor [PDF]

, 2010
Creep is the slow, time-dependent strain that occurs in a material under a constant strees (or load) at high temperature. High temperature is a relative term, dependent on the materials being evaluated. A typical creep curve is shown in Figure 1-1.
Condie, K. G., Kim, B. G., null D. L. Knudson, Sencer, B. H., null J. L. Rempe, Rempe, J. L., null K. G. Condie, null B. H. Sencer, Knudson, D. L., null B. G. Kim   +9 more
core   +1 more source

Multi-Scale evaluation of low-temperature performance in asphalt mixtures using not-notched semi-circular bending creep testing

Frontiers in Materials
To address the challenge of obtaining core samples directly from the field for low-temperature crack resistance tests of asphalt mixtures, this study utilizes the not-notched semi-circular bending (NN-SCB) creep test as a novel evaluation method.
Xinghao Xi, Xinghao Xi, Xinghao Xi, Dong Tang, Dong Tang, Zhenghe Wang, Zhenghe Wang, Naitian Zhang, Naitian Zhang   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Thermal aging of Gr. 91 steel in supercritical thermal plant and its effect on structural integrity at elevated temperature

Nuclear Engineering and Technology
In this study, the influence of thermal aging on structural integrity is investigated for Gr. 91 steel. A commercial grade Gr. 91 steel is used for the virgin material, and service-exposed Gr.
Min-Gu Won, Si-Hwa Jeong, Nam-Su Huh, Woo-Gon Kim, Hyeong-Yeon Lee   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source