Results 121 to 130 of about 177,805 (313)

Tensile and Compressive Constitutive Response of 316 Stainless Steel at Elevated Temperatures [PDF]

, 1983
Creep rate in compression is lower by factors of 2 to 10 than in tension if the microstructure of the two specimens is the same and are tested at equal temperatures and equal but opposite stresses.
Halford, G. R., Manson, S. S., Muralidharan, U.   +2 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Applicability analysis of induction bending process to P91 piping of PGSFR by high-temperature creep tests

Nuclear Engineering and Technology
This study evaluated the high-temperature creep structural integrity of P91 induction-bent piping for Prototype Gen-IV Sodium-cooled Fast Reactors (PGSFR) through specimen creep tests and bent pipe structural creep test alongside inelastic analysis ...
Tae-Won Na, Dong-Gi Song, Nak-Hyun Kim, Chang-Gyu Park, Junehyung Kim, Jong-Bum Kim   +5 more
doaj   +1 more source

Procedures for characterizing an alloy and predicting cyclic life with the total strain version of Strainrange Partitioning [PDF]

Procedures are presented for characterizing an alloy and predicting cyclic life for isothermal and thermomechanical fatigue conditions by using the total strain version of strainrange partitioning (TS-SRP). Numerical examples are given.
Halford, Gary R., Saltsman, James F.
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The viscoplasticity theory based on overstress applied to the modeling of a nickel base superalloy at 815 C [PDF]

Short term strain rate change, creep and relaxation tests were performed in an MTS computer controlled servohydraulic testing machine. Aging and recovery were found to be insignificant for test times not exceeding 30 hrs.
Krempl, E., Lu, H., Yao, D.
core   +1 more source

Constitutive modeling for isotropic materials [PDF]

, 1984
The unified constitutive theories for application to typical isotropic cast nickel base supperalloys used for air-cooled turbine blades were evaluated.
Dame, L. T., Laflen, J. H., Ramaswamy, V. G., Vanstone, R. H.   +3 more
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Creep degradation in oxide-dispersion-strengthened alloys [PDF]

Oxide dispersion strengthened Ni-base alloys in wrought bar form are studied for creep degradation effects similar to those found in thin gage sheet.
Whittenberger, J. D.
core   +1 more source