Results 111 to 120 of about 29,880 (311)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The development of finite element software for creep damage analysis
Creep deformation and failure in high temperature structures is a serious problem for industry and is becoming even more so under the current increasing pressures of power, economics and sustainability.
Liu, Dezheng
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, 2009 Currently, no standard mix design procedure is available for CIR-emulsion in Iowa. The CIR-foam mix design process developed during the previous phase is applied for CIR-emulsion mixtures with varying emulsified asphalt contents.
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The Progressive Development and Post-failure Behaviour of Deep-seated Landslide Complexes [PDF]
, 2011 The concept of progressive shear surface development remains to be fully understood. This study aims to investigate the mechanisms of progressive shear surface development to failure, and the subsequent post-failure behaviour, of deep-seated landslide ...
CAREY, JONATHAN,MARTIN +1 more
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Journal of Rock Mechanics and Geotechnical EngineeringThis paper presents an ultralow-frequency cyclic loading creep test system for rock salt. The system comprises five subsystems: a cyclic load generation system, a triaxial pressure chamber, a pressure and deformation monitoring system, a signal ...
Yinping Li +9 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Energy-based nonlinear damage creep model considering the influence of the concrete creep rate
Frontiers in MaterialsIn order to study the influence of confining pressure on the deformation of concrete, triaxial compression and creep tests under different confining pressures are carried out using a combination of laboratory tests and theoretical analysis.
Lu Wang
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The development of finite element software for creep deformation and damage analysis of weldment
This paper presents the development of finite element software for creep deformation and damage analysis of weldment. The development and benchmark test of the software under plane stress, plane strain, axisymmetric, and 3 dimensional cases were reported
Xu, Qiang +3 more
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