Results 111 to 120 of about 177,805 (313)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Creep of AU-4G1 aluminum alloy under incremental variation in stress Final report [PDF]

open access: yes
Linear viscoelastic analysis of incremental load test data on AU-4G1 aluminum alloy sheet subjected to tensile creep at 473 deg
Berkovits, A.
core   +1 more source

Performance of shallow anchor in ice-rich silt [PDF]

open access: yes, 2014
Thesis (M.S.) University of Alaska Fairbanks, 2014Shallow anchor systems have been widely used for decades due to their time and cost efficiency. Yet when it comes to cold regions like Alaska, new challenges caused by the harsh environment need to be ...
Lin, Chuang, 林闯
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Development of rock creep test system considering dynamic-static and ultralow-frequency cyclic loading

open access: yesJournal of Rock Mechanics and Geotechnical Engineering
This paper presents an ultralow-frequency cyclic loading creep test system for rock salt. The system comprises five subsystems: a cyclic load generation system, a triaxial pressure chamber, a pressure and deformation monitoring system, a signal ...
Yinping Li   +9 more
doaj   +1 more source

Experimental creep data for a built-up aluminum/titanium structure subjected to heating and loading [PDF]

open access: yes
Experimental creep, temperature, and strain data resulting from a laboratory experiment on a built-up aluminum/titanium structure are presented. The structure and the experiment are described in detail.
Jenkins, J. M., Montoya, C. A.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Energy-based nonlinear damage creep model considering the influence of the concrete creep rate

open access: yesFrontiers in Materials
In order to study the influence of confining pressure on the deformation of concrete, triaxial compression and creep tests under different confining pressures are carried out using a combination of laboratory tests and theoretical analysis.
Lu Wang
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Characteristics of Unloading Creep of Tuffaceous Sandstone in East Tianshan Tunnel under Freeze-Thaw Cycles

open access: yesAdvances in Materials Science and Engineering, 2019
The physicomechanical properties of tunnel surrounding rock are influenced by many factors such as the external environment and freeze-thaw cycles, especially in engineering in high cold regions. To understand the characteristics of freeze-thaw cycles on
Zhijun Zhou   +3 more
doaj   +1 more source

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