Results 71 to 80 of about 177,805 (313)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Controlled Environmental Effects on Creep Test Data of Woven Fabric Webbings for Inflatable Space Modules [PDF]

eveloping technologies for proposed lunar and Mars space exploration missions. Enhanced habitation sy g studied as potential habitats due to their inherent low mass and small launch volume.
Jones, Thomas C., Kenner, Winfred S., Le Boffe, Vincenzo M.   +2 more
core   +1 more source

Correlations Between Metallurgical Characterization Studies, Exploratory Mechanical Tests, and Continuum Mechanics Approaches to Constitutive Equations [PDF]

, 1983
Austenitic stainless steels, such as types 316 and 304, are widely used as pressure vessel materials in the temperature range of 425 to 650 C. Stainless steel specimens were tested to rupture at two different stress levels sigma and sigma 2 sigma 1 sigma
Moteff, J., Pugh, C. E., Swindeman, R. W.   +2 more
core   +1 more source

Mimicking complex dislocation dynamics by interaction networks [PDF]

, 2018
Two-dimensional discrete dislocation models exhibit complex dynamics in relaxation and under external loading. This is manifested both in the time-dependent velocities of individual dislocations and in the ensemble response, the strain rate.
Alava, Mikko J., Laurson, Lasse, Salmenjoki, Henri   +2 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

STUDY ON HIGH TEMPERATURE CREEP PROPERTIES OF DOMESTIC 800HT ALLOY USING SMALL PUNCH TEST TECHNIQUE

Jixie qiangdu
The creep performance of a domestic high⁃temperature incoloy 800HT alloy was tested using the small punch creep test technique.The CWA small punch creep test conversion method,and the EFS and MCH conversion methods were used respectively.The results of ...
JIANG Tao, GUAN KaiShu, ZHONG JiRu
doaj  

Viscoelastic plastic creep constitutive model based on energy conservation law and strain energy theory

Scientific Reports
On the basis of the law of conservation of energy, the three stages of rock creep are analyzed. The reasons for the difficulty in studying the accelerated creep stage of rocks using the traditional creep model are expounded.
Di Zhou, Xiangjin Tian, Shuguang Zhang, Wang Zeng, Minye Zhang, Yanchao Feng, Wenbo Liu, Xiang Huang, Mingzhuo Fan, Ye Sun   +9 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Understanding the creep behaviors and mechanisms of Mg-Gd-Zn alloys via machine learning

Journal of Magnesium and Alloys
Mg-Gd-Zn based alloys have better creep resistance than other Mg alloys and attract more attention at elevated temperatures. However, the multiple alloying elements and various heat treatment conditions, combined with complex microstructural evolution ...
Shuxia Ouyang, Xiaobing Hu, Qingfeng Wu, Jeong Ah Lee, Jae Heung Lee, Chenjin Zhang, Chunhui Wang, Hyoung Seop Kim, Guangyu Yang, Wanqi Jie   +9 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source