Results 81 to 90 of about 75,389 (334)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

ADMINISTRATIVE HISTORY OF CRES MUNICIPALITY 1952-1958

, 2022
U ovom je završnom radu obrađena Povijest uprave općine Cres u razdoblju od 1952. – 1958. godine, a koja je rezultat pravnog istraživanja obavljenog u Državnom arhivu u Rijeci.
Kolarić Ljubez, Emanuela
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Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Enquête de suivi des conditions de vie de la commune d'arrondissement de Wakhinane

, 2009
Document ...
CRES
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Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq

Nature Communications
Cis-regulatory elements (CREs) are pivotal in orchestrating gene expression throughout diverse biological systems. Accurate identification and in-depth characterization of functional CREs are crucial for decoding gene regulation networks during cellular ...
Ruitu Lyu, Yun Gao, Tong Wu, Chang Ye, Pingluan Wang, Chuan He   +5 more
doaj   +1 more source

Evolution of motif variants and positional bias of the cyclic-AMP response element

BMC Evolutionary Biology, 2007
Background Transcription factors regulate gene expression by interacting with their specific DNA binding sites. Some transcription factors, particularly those involved in transcription initiation, always bind close to transcription start sites (TSS ...
Famili A Fazel, Walker P Roy, Pan Youlian, Fang Hung, Smith Brandon, Sikorska Marianna   +5 more
doaj   +1 more source

Changes in lake level and trophy at Lake Vrana, a large karstic lake on the Island of Cres (Croatia), with respect to palaeoclimate and anthropogenic impacts during the last approx. 16,000 years

, 2000
A multi-proxy approach study (cladocerans, diatoms, geochemistry, plant macrofossils, pollen), was performed on a sediment core from Lake Vrana (Vransko Jezero), a large and deep karstic lake on the northern Adriatic island of Cres, Croatia. Considerable
R. Schmidt, J. Müller, Ruth Drescher‐Schneider, R. Krisai, K. Szeroczyńska, A. Barić   +5 more
semanticscholar   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Acuerdo específico entre la Universidad de la República y la Universidad Nacional de Córdoba (Argentina) para apoyar la organización de la III Conferencia Regional de Educación Superior de América Latina y el Caribe (CRES 2018)

, 2018
La Universidad Nacional de Córdoba (Argentina) contribuirá con la suma de USD 8.000,- como fondo de contribución para apoyar la organización de la III Conferencia Regional de Educación Superior de América Latina y el Caribe (CRES 2018)

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