Results 51 to 60 of about 5,030,707 (174)

Ring trial of 2nd generation RT‐QuIC diagnostic tests for sporadic CJD

Annals of Clinical and Translational Neurology, 2020
Objective Real‐time quaking‐induced conversion (RT‐QuIC) assays detect prion‐seeding activity in a variety of human biospecimens, including cerebrospinal fluid and olfactory mucosa swabs.
Christina D. Orrú, Bradley R. Groveman, Aaron Foutz, Matilde Bongianni, Franco Cardone, Neil McKenzie, Audrey Culeux, Anna Poleggi, Katarina Grznarova, Daniela Perra, Michele Fiorini, Xiaoqin Liu, Anna Ladogana, Marco Sbriccoli, Andrew G. Hughson, Stéphane Haïk, Alison J. Green, Michael D. Geschwind, Maurizio Pocchiari, Jiri G. Safar, Gianluigi Zanusso, Byron Caughey   +21 more
doaj   +1 more source

Early Remission of Cerebrospinal Fluid Interleukin‐6 After Initial Immunotherapy Predicts a Good Prognosis in Autoimmune Encephalitis

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Background Autoimmune encephalitis therapy requires adjusting the regimen based on therapeutic response; however, clinical indicators of this response remain unknown. Aim To determine the predictive capability of cerebrospinal fluid (CSF), electroencephalography (EEG), and brain magnetic resonance imaging (MRI) in identifying responders to ...
Yuta Madokoro, Yuto Uchida, Hiroyasu Inoue, Toyohiro Sato, Teppei Fujioka, Masayuki Mizuno, Shoji Kawashima, Masahiro Oomura, Noriyuki Matsukawa   +8 more
wiley   +1 more source

Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease [PDF]

, 2009
Several molecular subtypes of sporadic Creutzfeldt-Jakob disease have been identified and electroencephalogram and cerebrospinal fluid biomarkers have been reported to support clinical diagnosis but with variable utility according to subtype.
Summers, DM, Collins, S.J. (Steven), Brandel, J.P., Meissner, B, Meissner, B., Cras, P. (Patrick), Varges, D., Jansen, GH, Cras, Patrick, Pimentel, J, Brandel, J P, Smith, P., Taratuto, Ana Lia, van Duijn, Cornelia M., Begue, Christian, Summers, D. M., Summers, D.M., Jansen, G. H., Hewer, Ekkehard, Ladogana, Anna, Jansen, Gerard H, Will, Robert G., Schuur, M. (Maaike), Haik, S., Sanchez-Juan, P. (Pascual), Begue, C, Brandel, JP, Collins, S J, Heinemann, U., Haik, Stephane, Stokin, G B, Zerr, I., Schuur, M, Pimentel, Jose, Breithaupt, M., Taratuto, A, Sanchez-Juan, P, van Duijn, C., Stokin, GB, Breithaupt, Maren, Collins, SJ, Kallenberg, K., Sanchez-Juan, P., Collie, Donald A., Sanchez-Juan, Pascual, Hewer, E, Ladogana, A. (Anna), Schuur, M., Romero, C, Tikka-Kleemola, P. (Päivi), Cras, P., Schuur, Maaike, Romero, Carlos, Ladogana, A, Haik, S, Duijn, Cornelia, Stokin, G. B., Taratuto, A., Collie, D, Stokin, G.B., Brandel, J. P., Romero, C., Smith, P, Jansen, G H, Collie, D., Begue, C., Heinemann, U, Will, R G, Smith, Pete, Pocchiari, M., Collins, S. J., Pocchiari, Mauricio, Ladogana, A., Will, R. G., Will, RG, Meissner, Bettina, Summers, D M, Breithaupt, M, Jansen, G.H. (Gerard), Kallenberg, Kai, Hewer, E., Will, R.G., Cras, P, Zerr, I, Roberts, H., Jansen, Gerard H., Pocchiari, M, van Duijn, C, Pocchiari, M. (Maurizio), Varges, Daniel. A., Roberts, H, Brandel, Jean-Philippe, Kallenberg, K, Varges, D, Pimentel, J., et al.   +95 more
core   +3 more sources

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source

Variant Creutzfeldt-Jakob disease in the United Kingdom

, 2002
The Department of Health in England has issued the latest figures on known cases of Creutzfeldt-Jakob disease in the United Kingdom (UK), including cases of variant Creutzfeldt-Jakob disease (vCJD), the form of the disease thought to be linked to bovine ...
E Hoile
core   +3 more sources

Perceived Risks and Agency Trust Associated With Chronic Wasting Disease Over Time 慢性消耗性疾病相关感知风险与机构信任的时序变化研究

Wildlife Letters, EarlyView.
We examined changes in perceived risks associated with chronic wasting disease (CWD) and perceived trust in wildlife agencies over time across 10 studies in eight states. Results indicated that perceived risks to both deer and humans declined the longer the disease had been in a state. Results also indicated that agency trust evaluations were positive,
Jerry J. Vaske, Craig A. Miller
wiley   +1 more source

Movement Disorders in Prionopathies: A Systematic Review

Tremor and Other Hyperkinetic Movements, 2019
Background: Movement disorders are frequent features of prionopathies. However, their prevalence and onset remain poorly described. Methods: We performed a systematic review of case reports and case series of pathologically- and genetically confirmed ...
Federico Rodriguez-Porcel, Vinícius Boaratti Ciarlariello, Alok K. Dwivedi, Lilia Lovera, Gustavo Da Prat, Ricardo Lopez-Castellanos, Ritika Suri, Holly Laub, Ruth H. Walker, Orlando Barsottini, José Luiz Pedroso, Alberto J. Espay   +11 more
doaj   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Creutzfeldt–Jakob disease: A case report and differential diagnoses

Clinical Case Reports, 2022
Although sporadic Creutzfeldt–Jakob disease is a rare neurodegenerative disease and often difficult to diagnose at the earliest onset, meticulous clinical examination, electroencephalography, and neuroimaging findings will help in diagnosis.
Akash Raut, Anjila Thapa, Ashish Shrestha, Kamal Saud, Reema Rajbhandari, Shailendra Katwal   +5 more
doaj   +1 more source

Motives and barriers to blood donation among adults aged over 50 years: A qualitative analysis

Transfusion Medicine, EarlyView.
Abstract Background Ageing populations will increase demand for blood‐products and donors who supply them. While blood collection agencies (BCAs) typically target younger people to expand supply, recruiting donors aged 50+ is also a potential solution. However, few studies focus exclusively on this group.
Melissa K. Hyde, Barbara M. Masser, Rachel Thorpe, Aaron Akpu Philip, Amanda Salmon, Theresa L. Scott, Tanya E. Davison   +6 more
wiley   +1 more source