Results 131 to 140 of about 164,927 (267)

Positioning of Melflufen in Heavily Pretreated RRMM Patients: Real‐World Evidence in a Rapidly Evolving Therapeutic Landscape

European Journal of Haematology, EarlyView.
ABSTRACT Modern therapies have clearly marked the history of multiple myeloma (MM), leading to undisputed advantages in terms of sustained responses and prolonged survival, while progressively improving patients' quality of life. Nonetheless, disease recurrence and resistance to available therapies underscore the importance of identifying additional ...
K. Mancuso, S. Masci, M. Talarico, A. Vitale, S. Barbato, V. Solli, M. Puppi, I. Rizzello, L. Pantani, P. Tacchetti, M. Iezza, R. Restuccia, I. Sacchetti, E. Manzato, S. Ghibellini, S. Armuzzi, B. Taurisano, M. Cavo, E. Zamagni   +18 more
wiley   +1 more source

Suppression of Indoleamine 2,3‐Dioxygenase Enhances Immune Responses to the Therapeutic Vaccine for Chronic Hepatitis B

Hepatology Research, EarlyView.
Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami, Soranobu Ninomiya, Takayasu Ideta, Ayumu Kanbe, Toshihide Maeda, Daisuke Minowa, Daisuke Taguchi, Masaya Kubota, Hiroyasu Sakai, Kenji Imai, Yasuko Yamamoto, Hiroyasu Ito, Kuniaki Saito, Osamu Yoshida, Yoichi Hiasa, Masahito Shimizu   +15 more
wiley   +1 more source

Influence of Engine‐Driven NiTi Files on the Effectiveness and Technical Quality of Endodontic Treatment Performed by Undergraduate Students: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background In recent years, many universities have incorporated engine‐driven nickel‐titanium (NiTi) instruments into their undergraduate endodontic programs, aiming to enhance the efficiency and precision of root canal treatments. While these techniques might offer advantages, concerns remain regarding their implementation, particularly in ...
Monique Corrêa Rocha Ferrari Barbosa, Elidiane Elias Ribeiro, Karem Paula Pinto, Ana Flávia Almeida Barbosa, Emmanuel João Nogueira Leal da Silva, Luciana Moura Sassone   +5 more
wiley   +1 more source

Genres of Paradoxical IS Theorising: Of Chaos–Puzzles and Spear–Shields

Information Systems Journal, EarlyView.
ABSTRACT Paradox is a powerful lens for theorising information systems (IS) phenomena. However, as scholars apply the term to fundamentally different phenomena, ‘paradox’ risks dilution. Much confusion stems from conflating two concepts under the same English label ‘paradox’: chaos–puzzles (seemingly impossible ideas, aligned with the Chinese term ‘bei
Blair Wang, Raffaele F. Ciriello, Lars Mathiassen   +2 more
wiley   +1 more source

Evaluation of Antimicrobial and Antibiofilm Effects of Almond (Prunus amygdalus) Green Skin Extract on Pseudomonas aeruginosa and Staphylococcus aureus Isolates

Canadian Journal of Infectious Diseases and Medical Microbiology
Conclusion: The combination of antibiotics with almond green skin extract enhances bactericidal and antibiofilm properties against clinical isolates of S. aureus and P. aeruginosa.
Fatemeh Keshavarz, Shima Gharibi, Farkhondeh Poursina, Hamed Fakhim   +3 more
doaj   +1 more source

Narratives Contextualizing Numeric Disclosures: Insights From Earnings Calls

Journal of Business Finance &Accounting, EarlyView.
ABSTRACT We investigate how narrative disclosures during earnings conference calls (ECCs) provide context for quantitative numeric disclosures in quarterly earnings releases, enhancing their informativeness. Drawing on a large sample of 34,918 quarterly ECCs from 1621 US‐listed firms from 2007 to 2020, we extract interpretable textual attributes—such ...
Imelda Taraj, Ranik Raaen Wahlstrøm
wiley   +1 more source

Association between thyroid dysfunction and cognitive impairment in type 2 diabetes mellitus: A cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
Hypothyroidism is an independent risk factor for cognitive impairment in T2DM patients, with a progressive risk increase associated with higher TSH levels. These findings underscore the importance of integrating thyroid function evaluation into the cognitive assessment and management strategy for this patient population.
Mengmeng Zheng, Xing Zhong, Ping Zhang
wiley   +1 more source

Family quality‐of‐life burden in chronic spontaneous urticaria: A multicentre study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Poor control of chronic spontaneous urticaria (CSU) significantly worsens family members' quality of life, especially in emotional, physical, and social domains. Higher disease severity was linked to increased caregiving burden and household expenditures, highlighting the need for family‐centred CSU care and support across diverse global populations ...
Beatrice Martinez Zugaib Abdalla, Roberta Fachini Jardim Criado, Kanokvalai Kulthanan, Emek Kocatürk, Ivan Cherrez‐Ojeda, Ana Maria Giménez‐Arnau, Marcus Maurer, Luis Felipe Ensina, Jonathan A. Bernstein, Michihiro Hide, Sergio Duarte Dortas Junior, Solange Oliveira Rodrigues Valle, Gabriela Dias, Paraskevi Xepapadak, Priyanshi Dangi, Indrashis Podder, Vesna Trajkova, Natasa Teovska Mitrevska, Iman Hamed Nasr, Bushra Al Hinai, Joanna Bartosińska, Dorota Krasowska, Paulina Szczepanik‐Kułak, Hilal Gungor, Deniz Ozceker, Kübra Çiçek, Esen Özkaya, Yasemin Erdem, Mücahit Ergün, Mustafa Tosun, Rabia Oztas Kara, Jie Li, Anastasia Allenova, Paulo Ricardo Criado   +33 more
wiley   +1 more source

Towards an integrated molecular understanding of plant hormones

Journal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain, Marie‐Laure Fauconnier, Manon Genva   +2 more
wiley   +1 more source

e-CRF Manager

, 2012
The overall project objective is to develop a web portal that will create a Case Report Form (CRF). A Case Report Form (CRF) is a document that the investigator uses to record all the information regarding a patient during a medical study or clinical trial.
openaire   +3 more sources