Results 111 to 120 of about 164,927 (267)

Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Magnetic resonance imaging using hyperpolarized (HP) [1‐13C]‐pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi‐quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular ...
James A. Bankson, Joshua S. Niedzielski, Collin J. Harlan, Yunyun Chen, Christopher M. Walker, Philip L. Lorenzi, Lin Tan, Vikas Kundra, Matthew E. Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B. Peterson, Clifton D. Fuller, Vlad C. Sandulache, Stephen Y. Lai   +18 more
wiley   +1 more source

The Diminished Cardiorespiratory Fitness in Cardiovascular-Kidney-Metabolic Syndrome

Journal of Multidisciplinary Healthcare
Yuting Liu,1 Yanting Liang,1 Huan Ma,2 Hengyuan Gao,3,4 Xinzhou Zhang1,5 1Department of Nephrology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and ...
Liu Y, Liang Y, Ma H, Gao H, Zhang X
doaj  

Structural and Functional Insights into CRF Peptides and Their Receptors

Biology
Corticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes.
Minos-Timotheos Matsoukas, Vasilis Panagiotopoulos, Vlasios Karageorgos, George P. Chrousos, Maria Venihaki, George Liapakis   +5 more
doaj   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou, Anne Auperin, Jôel Guigay, Sébastien Salas, Sebastien Benzekry   +4 more
wiley   +1 more source

The effects of corticotropin-releasing factor on motor learning

Scientific Reports
Corticotropin-releasing factor (CRF) is mainly secreted from the hypothalamic paraventricular nuclei and plays a crucial role in stress-related responses. Recent studies have reported that CRF is a neuromodulator in the central nervous system.
Eri Takeuchi, Tomomi Hatanaka, Takatoshi Iijima, Minoru Kimura, Akira Katoh   +4 more
doaj   +1 more source

An electroencephalography sleep staging model based on bidirectional Mamba combining synergistic attention with interactive convolution

Sleep Research, EarlyView.
Abstract Background This study presents SIMSleepSM, a novel single‐channel electroencephalography (EEG) sleep staging model. It addresses two primary challenges: insufficient modeling of long‐range temporal dependencies combined with limited multi‐scale feature extraction, and poor accuracy in identifying the N1 stage.
Ya‐mei Xu, Ding‐Yuan An
wiley   +1 more source

Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4‐Mediated Ferroptosis

Small, EarlyView.
ABSTRACT Pancreatic cancer, one of the most malignant solid tumors with the poorest prognosis, is commonly treated with gemcitabine (GEM)‐based systemic chemotherapy. However, chemoresistance remains a significant therapeutic challenge. Ferroptosis, a novel form of programmed cell death, has demonstrated exceptional susceptibility in chemoresistant ...
Jiaqiang Ren, Shuai Wu, Tong Su, Hugang Li, Jiachun Ding, Fan Chen, Jiantao Mo, Jie Li, Zheng Wang, Liang Han, Zheng Wu   +10 more
wiley   +1 more source

Incremental upper bound modeling of concrete failures in timber‐concrete notched connections

Structural Concrete, EarlyView.
Abstract This paper introduces a novel theoretical framework for developing incremental upper bound solutions, which is applied to predict the response of two local concrete failures in timber‐concrete composite (TCC) decks with notched connections. The new approach enables a prediction of the capacity at the onset of failure as well as the entire post‐
Peter K. Rasmussen, Linh C. Hoang, Jesper H. Sørensen, Bent Feddersen   +3 more
wiley   +1 more source

Maternal Obesity, Gestational Diabetes Mellitus and Offspring's Body Mass Index Trajectories From Birth to Age 6 Years: Glucose in Relation to Women and Babies' Health (GrownB) Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine whether offspring born to mothers with overweight/obesity, gestational diabetes mellitus (GDM) or both exhibit different body mass index (BMI) trajectories from birth to 6 years old. Design Retrospective cohort study. Setting The Glucose in Relation to Women and Babies' Health (GrownB) Study at the University of California,
Cheng‐Tzu Hsieh, Xinyue Liu, Xiang Li, Rana F. Chehab, Yeyi Zhu, Liwei Chen   +5 more
wiley   +1 more source

Eclampsia Incidence, Management and Outcomes Across Multi‐Country Surveillance Cohorts: Individual Participant Data Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To estimate the incidence of eclampsia, characterise maternal and perinatal profiles, and document outcomes across seven countries within the International Obstetric Survey System and identify inter‐country differences that may improve maternal and perinatal care.
Silvia Salvi, Donatella Mandolini, Kitty W. M. Bloemenkamp, Catherine Deneux‐Tharaux, Hilde Marie Engjom, Lachmi R. Kodan, Diane Korb, Alexandra Krištúfková, Kari Klungsøyr, Ann Langedock, Camilla Tjønneland Mentzoni, Liam McCullough, Rema Ramakrishnan, T. P. (Timme) Schaap, Aurélien Seco, Griet Vandenberghe, Kim J. C. Verschueren, Serena Donati, on behalf of INOSS Group (International Network of Obstetric Survey Systems)   +18 more
wiley   +1 more source