Results 141 to 150 of about 29,752 (188)
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Journal of Clinical Endocrinology & Metabolism, 1997
Recently, the presence of immunoreactive corticotropin-releasing factor (IrCRF) in the thecal-stromal cells of the human ovary and the ability of CRF to suppress estrogen production by human granulosa cells in vitro have been reported. To understand the functional role of ovarian CRF requires characterization of the human ovarian CRF system, which ...
H, Asakura, I H, Zwain, S S, Yen
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Recently, the presence of immunoreactive corticotropin-releasing factor (IrCRF) in the thecal-stromal cells of the human ovary and the ability of CRF to suppress estrogen production by human granulosa cells in vitro have been reported. To understand the functional role of ovarian CRF requires characterization of the human ovarian CRF system, which ...
H, Asakura, I H, Zwain, S S, Yen
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N-glycosylation of CRF receptor type 1 is important for its ligand-specific interaction
American Journal of Physiology-Endocrinology and Metabolism, 2001The corticotropin-releasing factor (CRF) receptor type 1 (CRFR1) contains five potential N-glycosylation sites: N38, N45, N78, N90, and N98. Cells expressing CRFR1 were treated with tunicamycin to block receptor glycosylation. The nonglycosylated receptor did not bind the radioligand and had a decreased cAMP stimulation potency in response to CRF.
I Q, Assil, A B, Abou-Samra
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Novel high‐affinity photoactivatable antagonists of corticotropin‐releasing factor (CRF)
European Journal of Biochemistry, 2000Novel photoactivatable antagonists of human/rat corticotropin‐releasing factor (h/rCRF) have been synthesized and characterized. The N‐terminal amino acid d‐phenylalanine in astressin {cyclo(30–33) [d‐Phe12, Nle21,38, Glu30, Lys33]h/rCRF‐(12–41)}, a potent CRF peptide antagonist, was replaced by a phenyldiazirine, the 4‐(1‐azi‐2,2,2‐trifluoroethyl ...
I, Bonk, A, Rühmann
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Journal of Neurocytology, 2003
Corticotropin releasing factor (CRF) is present in the adult, as well as in the embryonic and postnatal rodent cerebellum. Further, the distribution of the type 1 CRF receptor has been described in adult and postnatal animals. The focus of the present study is to determine the distribution and cellular relationships of the type 1 CRF receptor (CRF-R1 ...
James S, King, Georgia A, Bishop
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Corticotropin releasing factor (CRF) is present in the adult, as well as in the embryonic and postnatal rodent cerebellum. Further, the distribution of the type 1 CRF receptor has been described in adult and postnatal animals. The focus of the present study is to determine the distribution and cellular relationships of the type 1 CRF receptor (CRF-R1 ...
James S, King, Georgia A, Bishop
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Behavioural Brain Research, 2014
Corticotropin-releasing factor (CRF) plays a critical role in the mediation of physiological and behavioral responses to stressors. In the present study, we investigated the role played by the CRF system within the dorsomedial hypothalamus (DMH) in the modulation of anxiety- and panic-related responses.
Silva, Mariana Santos Carvalho de Faria UNIFESP +5 more
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Corticotropin-releasing factor (CRF) plays a critical role in the mediation of physiological and behavioral responses to stressors. In the present study, we investigated the role played by the CRF system within the dorsomedial hypothalamus (DMH) in the modulation of anxiety- and panic-related responses.
Silva, Mariana Santos Carvalho de Faria UNIFESP +5 more
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Neuroscience and Behavioral Physiology, 2016
Corticotropin-releasing factor (CRF) is involved in the regulation of pain sensitivity and can cause an analgesic effect in animals and humans. The aim of the study was to investigate the involvement of CRF1 and CRF2 receptors in CRF-induced analgesic effect (after intraperitoneal injection) on somatic pain sensitivity in conscious rats.
N. I. Yarushkina +2 more
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Corticotropin-releasing factor (CRF) is involved in the regulation of pain sensitivity and can cause an analgesic effect in animals and humans. The aim of the study was to investigate the involvement of CRF1 and CRF2 receptors in CRF-induced analgesic effect (after intraperitoneal injection) on somatic pain sensitivity in conscious rats.
N. I. Yarushkina +2 more
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Neurogastroenterology & Motility, 2012
AbstractBackground Peripheral corticotrophin‐releasing factor (CRF) plays an important role in stress‐induced alterations of gastrointestinal motility. CRF injected peripherally inhibits gastric emptying, but its effect on gastric contractions has not been clarified in freely moving conscious rats.Methods Intraluminal gastric pressure waves were ...
T, Nozu +4 more
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AbstractBackground Peripheral corticotrophin‐releasing factor (CRF) plays an important role in stress‐induced alterations of gastrointestinal motility. CRF injected peripherally inhibits gastric emptying, but its effect on gastric contractions has not been clarified in freely moving conscious rats.Methods Intraluminal gastric pressure waves were ...
T, Nozu +4 more
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Hormones and Behavior, 2014
Corticotropin-releasing factor (CRF) plays a critical role in the mediation of physiological and behavioral responses to stressors. In the present study, we investigated the role played by the CRF system within the medial amygdala (MeA) in the modulation of anxiety and fear-related responses.
Jéssica E, Vicentini +4 more
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Corticotropin-releasing factor (CRF) plays a critical role in the mediation of physiological and behavioral responses to stressors. In the present study, we investigated the role played by the CRF system within the medial amygdala (MeA) in the modulation of anxiety and fear-related responses.
Jéssica E, Vicentini +4 more
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Biochemical and Biophysical Research Communications, 2000
Agonist-induced phosphorylation of the human corticotropin-releasing factor type 1 receptor (hCRF(1)-R) was investigated using an influenza hemagglutinin (HA) epitope-tagged receptor transiently expressed in COS-7 cells. The HA-hCRF(1)-R migrated as a broad band (M(r) 60,000-70,000) in SDS-PAGE and showed increased mobility (M(r) approximately 48,000 ...
R L, Hauger +4 more
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Agonist-induced phosphorylation of the human corticotropin-releasing factor type 1 receptor (hCRF(1)-R) was investigated using an influenza hemagglutinin (HA) epitope-tagged receptor transiently expressed in COS-7 cells. The HA-hCRF(1)-R migrated as a broad band (M(r) 60,000-70,000) in SDS-PAGE and showed increased mobility (M(r) approximately 48,000 ...
R L, Hauger +4 more
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Alcoholism: Clinical and Experimental Research, 2001
Background: The purpose of this work was to determine the influence of acute alcohol treatment, injected intraperitoneally, on the hypothalamic‐pituitary‐adrenal axis of mice that lack type 1 receptor for corticotropin‐releasing factor (CRFR1).Methods: CRFR1‐deficient (CRFR1−/−), heterozygous (CRFR1±), and wild‐type (CRFR1+/+) mice were generated and
S, Lee +4 more
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Background: The purpose of this work was to determine the influence of acute alcohol treatment, injected intraperitoneally, on the hypothalamic‐pituitary‐adrenal axis of mice that lack type 1 receptor for corticotropin‐releasing factor (CRFR1).Methods: CRFR1‐deficient (CRFR1−/−), heterozygous (CRFR1±), and wild‐type (CRFR1+/+) mice were generated and
S, Lee +4 more
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