Results 151 to 160 of about 29,752 (188)
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2022
AbstractChronic unpredictable stress (CUS) impairs cognitive flexibility in rats, particularly when faced with additional mild acute stress (AS). We tested the hypothesis that this impairment is associated with alterations in dopamine activity in the dorsal striatum driven by corticotropin-releasing-factor receptor type 1 (CRFR1) in the substantia ...
S Becchi +5 more
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AbstractChronic unpredictable stress (CUS) impairs cognitive flexibility in rats, particularly when faced with additional mild acute stress (AS). We tested the hypothesis that this impairment is associated with alterations in dopamine activity in the dorsal striatum driven by corticotropin-releasing-factor receptor type 1 (CRFR1) in the substantia ...
S Becchi +5 more
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Fundamental & Clinical Pharmacology, 1999
Abstract—Corticotropin‐releasing factor (CRF) is a hypothalamic 41‐amino acid peptide which stimulates corticotropin (ACTH) release from the anterior pituitary and is also involved in the body response to stress. CRF, receptors represent a potential target for novel antidepressant/anxiolytic drugs. The aim of the present study was to search for a human
P, Schoeffter +4 more
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Abstract—Corticotropin‐releasing factor (CRF) is a hypothalamic 41‐amino acid peptide which stimulates corticotropin (ACTH) release from the anterior pituitary and is also involved in the body response to stress. CRF, receptors represent a potential target for novel antidepressant/anxiolytic drugs. The aim of the present study was to search for a human
P, Schoeffter +4 more
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Journal of Comparative Neurology, 2004
AbstractCorticotropin‐releasing factor receptor type 1, CRF1, plays a prominent role in the hypothalamic‐pituitary‐adrenal (HPA) axis and is implicated in the autonomic and behavioral responses to stress. Dysregulation of the CRF system may underlie the pathophysiology of several disorders, including depression and anxiety.
Walter A, Kostich +3 more
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AbstractCorticotropin‐releasing factor receptor type 1, CRF1, plays a prominent role in the hypothalamic‐pituitary‐adrenal (HPA) axis and is implicated in the autonomic and behavioral responses to stress. Dysregulation of the CRF system may underlie the pathophysiology of several disorders, including depression and anxiety.
Walter A, Kostich +3 more
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Brain Research, 2002
Molecular studies point to a role for the type 1 corticotropin-releasing factor receptor (CRF(1)) in anxiogenic-like and activating effects of CRF and stress. However, CP-154,526, a selective CRF(1) antagonist, has yielded mixed results in such tests. Few studies have examined the behavioral effects of other CRF(1) antagonists.
Eric P, Zorrilla +4 more
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Molecular studies point to a role for the type 1 corticotropin-releasing factor receptor (CRF(1)) in anxiogenic-like and activating effects of CRF and stress. However, CP-154,526, a selective CRF(1) antagonist, has yielded mixed results in such tests. Few studies have examined the behavioral effects of other CRF(1) antagonists.
Eric P, Zorrilla +4 more
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Molecular Brain Research, 1997
We investigated the ability of a moderately intoxicating dose of alcohol (3 g/kg, injected i.p. 3 h earlier) to up-regulate the genetic expression of CRF receptor type 1 (CRF-R1) and 2 (CRF-R2alpha) in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus as well as in the amygdala.
S, Lee, C, Rivier
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We investigated the ability of a moderately intoxicating dose of alcohol (3 g/kg, injected i.p. 3 h earlier) to up-regulate the genetic expression of CRF receptor type 1 (CRF-R1) and 2 (CRF-R2alpha) in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus as well as in the amygdala.
S, Lee, C, Rivier
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1998
The purpose of this study was to compare the effect of an acute versus a chronic immobilization stress on the genetic expression of c- fos and corticotropin-releasing factor type 1 receptor (CRF1receptor) in the paraventricular nucleus (PVN) of the rat hypothalamus.
B, Bonaz, S, Rivest
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The purpose of this study was to compare the effect of an acute versus a chronic immobilization stress on the genetic expression of c- fos and corticotropin-releasing factor type 1 receptor (CRF1receptor) in the paraventricular nucleus (PVN) of the rat hypothalamus.
B, Bonaz, S, Rivest
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Psychopharmacology, 2006
Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapseThis present study was designed to investigate the potential role for the HPA axis in the cue- and methamphetamine-induced reinstatement of extinguished methamphetamine ...
M C, Moffett, N E, Goeders
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Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapseThis present study was designed to investigate the potential role for the HPA axis in the cue- and methamphetamine-induced reinstatement of extinguished methamphetamine ...
M C, Moffett, N E, Goeders
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Drug Development Research, 2005
AbstractSince the discovery of corticotropin‐releasing factor (CRF), extensive research has attempted to provide novel treatment strategies for diseases related to the malfunctions of the hypothalamic–pituitary–adrenocortical (HPA) system. In depression, cerebrospinal fluid levels of CRF are higher than that in normal individuals.
Chen Chen, Dimitri E. Grigoriadis
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AbstractSince the discovery of corticotropin‐releasing factor (CRF), extensive research has attempted to provide novel treatment strategies for diseases related to the malfunctions of the hypothalamic–pituitary–adrenocortical (HPA) system. In depression, cerebrospinal fluid levels of CRF are higher than that in normal individuals.
Chen Chen, Dimitri E. Grigoriadis
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Life Sciences
Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric illness caused by traumatic or life-threatening events and manifesting as various symptoms, including intrusive re-experiences of trauma, avoidance behaviors, hyperarousal, and negative changes in perception and mood.Current monoamine-based medications commonly exhibit limited ...
Mijin, Jeon +11 more
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Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric illness caused by traumatic or life-threatening events and manifesting as various symptoms, including intrusive re-experiences of trauma, avoidance behaviors, hyperarousal, and negative changes in perception and mood.Current monoamine-based medications commonly exhibit limited ...
Mijin, Jeon +11 more
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Type 2 chronic inflammatory diseases: targets, therapies and unmet needs
Nature Reviews Drug Discovery, 2023P V Kolkhir +2 more
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